Results 41 to 50 of about 276,669 (295)

Clinical analysis of 11 cases of nocardiosis

Open Medicine, 2021
Nocardiosis is a rare, life-threatening, opportunistic, and suppurative infection. Its clinical manifestation lacks specificity, which makes early diagnosis difficult.
Li Yiqing, Tang Ting, Xiao Jie, Wang Jieyu, Li Boqi, Ma Liping, Xie Shuangfeng, Nie Danian   +7 more
doaj   +1 more source

Clinical and laboratory profile in confirmed vs. suspected septic arthritis patients and its relevance in decision making: A comparative cross-sectional study

Chinese Journal of Traumatology, 2021
Purpose: There were 10%–30% of patients with adult-onset septic arthritis (SA) exhibiting sterile synovial fluid (SF), and the uncertainty in the determining diagnosis of these patients posed a challenge in management.
Sandeep K. Nema, Suman Kumar Basel, Jose Austine, Kiyana Mirza   +3 more
doaj   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Higher risk of tuberculosis reactivation when anti-TNF is combined with immunosuppressive agents. A systematic review of randomized controlled trials [PDF]

, 2014
Objective. Treatment with tumour necrosis factor antagonists (anti-TNF) has been recognized as a risk factor for tuberculosis (TB) reactivation. Our aim was to evaluate risk of TB reactivation in rheumatologic and non-rheumatologic diseases treated with ...
Armuzzi, Alessandro, Bruzzese, Vincenzo, Gatta, Luigi, Hassan, Cesare, Laganà, Bruno, Lorenzetti, Roberto, Migliore, Alberto, Picchianti Diamanti, Andrea, Ridola, Lorenzo, Zullo, Angelo   +9 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

La terapia immunosoppressiva nel trapianto di rene

Giornale di Clinica Nefrologia e Dialisi, 2019
Immunosuppressive therapy in renal transplantation can be distinguished in induction therapy and maintenance therapy. Induction therapy is an intense immunosuppressive therapy administered at the time of kidney transplantation to reduce the risk of acute
Aris Tsalouchos, Maurizio Salvadori
doaj   +1 more source

Phaeohyphomycosis in renal transplantation: report of two cases [PDF]

Anais Brasileiros de Dermatologia, 2016
Phaeohyphomycosis is an infection caused by a filamentous fungus that contains pigment melanin in its cell wall. We report two cases caused by Exophiala sp.
Walmar Roncalli Pereira de Oliveira, Maria Fernanda Longo Borsato, Maria Luiza Ducati Dabronzo, Cyro Festa Neto, Larissa Aragão Rocha, Ricardo Spina Nunes   +5 more
doaj   +1 more source

Guidance on noncorticosteroid systemic immunomodulatory therapy in noninfectious uveitis: fundamentals of care for uveitis (focus) initiative [PDF]

, 2018
Topic: An international, expert-led consensus initiative to develop systematic, evidence-based recommendations for the treatment of noninfectious uveitis in the era of biologics.
Acharya, Nisha, Adan, Alfredo, Agrawal, Rupesh, Akkoc, Nurullah, Al Ghamdi, Saed, Al Ghamdi, Turki, Al Saati, Anood, Al-Dhibi, Hassan A., Al-Shamarani, Mohamed, Alsabaani, Nasser, Bachta, Artur, Barisani-Asenbauer, Talin, Beare, Nicholas, Belga Ottoni Porto, Fernanda, Blanco, Ricardo, Brézin, Antoine P., Carreño, Ester, Chan Sook Yee, Anita, Chandran, Vinod, Chiquet, Christophe, Cimbalas, Andrius, Cimino, Luca, Cordero-Coma, Miguel, Correspondence information about the author FMedSci, FRCOphth, Cristobal, Couto, Cuevas, Miguel, Davis, Janet L., de Boer, Joke, de la Torre, Alejandra, De Schryver, Ilse, Derzko-Dzulynsky, Larissa, Diaz-Valle, David, Dick, Andrew D., Dick, FRCOphth Andrew D., Dick†, FRCOphth Andrew D., Eugenia Duran Merino, Claudia, Eurico da Fonseca, João, Facsko, Andrea, Figueira, Luis, FMedSci,, Fonollosa, Alejandro, Fortin, Eric, FRCOphth,, FRCPCH, FRCP, FRCS, FRCOphth, FRCSEd(Ophth), FRCOphth, Gale, Richard, Galeazzi, Mauro, Garcia, Sandra, Gašperšič, Nataša, Goldstein, Debra, Guedes, Marta, Guex-Crosier, Yan, Gul, Ahmet, Hamam, Rola, Haroon, Muhammad, Hasegawa, Kenichi, Hee Chng, Hiok, Heiligenhaus, Arnd, Hisae Yamamoto, Joyce, Hooper, Claire, Hwang, De-Kuang, Hwang, Yih-Shiou, Jr., Rubens Belfort, Juanola, Xavier, Kaburaki, Toshikatsu, Kadayifcilar, Sibel, Kempen, John, Kezuka, Takeshi, Kherani, Amin, Kiak Lim, Wee, Kirsimäe, Maarja, Kotaniemi, Kaisu, Kraut, Aleksandra, Kubicka-Trząska, Agnieszka, Kuffova, Lucia, Lightman, Susan, Lim, Lyndell, MA, MD, Maria Garcia Ruiz de Morales, Jose, Massimo Accorinti, MBChB(Hons), McCluskey, Peter, McGuire, Mairide, MD,, MD,, MD,, MD,, MD†,, Mirabelli, Pierfrancesco, Miserocchi, Elisabetta, Misiuk-Hojło, Marta, Muccioli, Cristina, Murphy, Conor, Murray, Philip I., Muñoz, Santiago, Nagy, Zoltan, Namba, Kenichi, Nascimento, Heloisa, Neri, Piergiorgio, Nguyen, Quan, O'Gradaigh, Donncha, Omair, Mohammed, Otsa, Kati, Ozyazgan, Yilmaz, Pablo, Franco, PAROLI, Maria Pia, Phaik Chee, Soon, PhD, MD, PhD, MD, PhD, MD, PhD, MD, Pleyer, Uwe, Poór, Gyula, Proença, Rui, Rabinovitch, Theodore, Ramanan, Athimalaipet V., Read, Russell, Rebrov, Margarita, Recillas-Gispert, Claudia, Rosenbaum, James T., Rothova, Aniki, Salah, Sawsen, Salek, Sherveen, Schwartzman, Sergio, Seve, Pascal, Sharma, Srilakshmi, Siak, Jay, Sims, Joanne, Sohár, Nicolette, Sonoda, Koh-Hei, Steeples, Laura, Suhler, Eric, Szepessy, Zsuzsanna, Szántó, Sándor, Tappeiner, Christoph, the author FMedSci, Email, Thorne, Jennifer, Tugal Tutkun, Ilknur, Turno-Kręcicka, Anna, Van Calster, Joachim, van der Horst-Bruinsma, Irene, Vidovič Valentinčič, Nataša, Vitale, Albert, Voorduin Ramos, Stephanie, Vukojevic, Nenad, Wakefield, Denis, Willermain, François, Yalcindag, Nilufer, Yeh, Stephen, Zemaitiene, Reda, Ziouzina, Olga   +150 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Baricitinib for atopic dermatitis patients who responded inadequately to dupilumab treatment: First daily practice results

JEADV Clinical Practice, 2022
Background Baricitinib is the first JAK inhibitor registered for the treatment of moderate‐to‐severe atopic dermatitis (AD). Efficacy and safety were shown in clinical trials, but daily practice data is sparse.
Linde deWijs, Corine Schreurs, Anne Schlösser, Tamar Nijsten, Dirk Jan Hijnen   +4 more
doaj   +1 more source