Results 41 to 50 of about 1,824,517 (243)

Impact of immunosuppressive agents on clinical manifestations and outcome of staphylococcus aureus bloodstream infection: a propensity score-matched analysis in 2 large, prospectively evaluated cohorts

, 2021
BACKGROUND: Staphylococcus aureus bloodstream infection (SAB) is a common, life-threatening infection. The impact of immunosuppressive agents on the outcome of patients with SAB is incompletely understood.
Tim Filla (14348202), Jonathan Edgeworth (471617), Laura Morata (3091068), Chun-Hsing Liao (554963), Achim J Kaasch (16193357), Emmanuel Nsutebu (16158935), Johannes Camp (8304528), Robert Tilley (15893375), others (6644544), Hong Bin Kim (9392260), Matt Scarborough (16268648), Lina Glaubitz (16294508), Luis Eduardo López-Cortés (8627994), Frieder Fuchs (9972395), Martin Llewelyn (4461757)   +14 more
core   +3 more sources

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

La terapia immunosoppressiva nel trapianto di rene

Giornale di Clinica Nefrologia e Dialisi, 2019
Immunosuppressive therapy in renal transplantation can be distinguished in induction therapy and maintenance therapy. Induction therapy is an intense immunosuppressive therapy administered at the time of kidney transplantation to reduce the risk of acute
Aris Tsalouchos, Maurizio Salvadori
doaj   +1 more source

Cardiovascular effects of immunosuppression agents

Frontiers in Cardiovascular Medicine, 2022
Immunosuppressive medications are widely used to treat patients with neoplasms, autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin inhibitors, mammalian target of rapamycin (mTOR) inhibitors, and purine synthesis ...
Aly Elezaby, Aly Elezaby, Ryan Dexheimer, Karim Sallam, Karim Sallam   +4 more
doaj   +1 more source

Small intestinal bacterial overgrowth syndrome in children with idiopathic nephritic syndrome treated with immunosuppressive agents [PDF]

, 2016
Small intestinal bacterial overgrowth syndrome is defined as an increased number of non-pathogenic bacteria over 105 microorganisms in one millilitre of intestinal contents in the initial part of the small intestine. Predisposing disorders include e.g.
Marcin Tkaczyk, Tkaczyk, Marcin, Siniewicz-Luzeńczyk, Katarzyna, Katarzyna Siniewicz-Luzeńczyk   +3 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The Newest Medications in Kidney Transplantation and their Mechanisms of Action

Urology Journal, 2004
Purpose: In recent years, many new immunosuppressive drugs have been discovered and developed for clinical use in transplantation. This review focuses on new drugs and novel strategies that have been shown to have immunosuppressive activity in patients ...
Mahboob Lesan Pezeshki
doaj  

Extracellular matrix remodeling and immune reprogramming drive residual tumor progression of liver cancer after incomplete microwave ablation

Molecular Oncology, EarlyView.
Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu, Yubei He, Nikolaus Berndt, Michael Mülleder, Kathrin Textoris‐Taube, Jing Guo, Matthias Stechele, Justus Ramtke, Shraga Nahum Goldberg, Lynn Jeanette Savic   +9 more
wiley   +1 more source

Drug Utilisation Pattern in the Inpatient Management of Psoriasis: A Retrospective Study from a Tertiary Care Centre in Karnataka, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Psoriasis is a chronic immune-mediated inflammatory disorder that often requires multidrug therapy during hospitalisation. Evaluation of drug utilisation patterns helps assess rational prescribing practices and adherence to treatment ...
D Karthik, Anil Pandhrinath Hogade
doaj   +1 more source