Results 51 to 60 of about 1,824,517 (243)

Immunosuppressive treatment for multifocal motor neuropathy

, 2002
Multifocal motor neuropathy is a distinct clinical entity characterised by progressive, predominantly distal, asymmetrical limb weakness and minimal sensory abnormality.
E. Nobile-Orazio, RAC Hughes, R. A. Hughes, T. Umapathi, JM Léger, T Umapathi, J. M. Léger, E Nobile-Orazio   +7 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Advance of immune checkpoint inhibitors and clinical trials in glioma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2020
Glioma is the most common primary intracranial malignant tumor, and glioblastoma has the worst prognosis. In recent years, immunotherapy targeting immune checkpoints has shown promising results in various solid tumors, and has also become a potential ...
Xiao⁃jie DING, Di CHEN, Chao TANG, Yu YAO   +3 more
doaj  

Pulse therapy: Opening new vistas in treatment of pemphigus

Journal of Family Medicine and Primary Care, 2019
Pemphigus is comprised of a group of life-threatening autoimmune diseases that is characterized by circulating IgG antibodies targeting several types of keratinocyte antigens.
Subhasish Mustafi, Rupam Sinha, Samhita Hore, Suman Sen, Subhadeep Maity, Pritha Ghosh   +5 more
doaj   +1 more source

Single-Cell Profiling of Kidney Transplant Recipients With Immunosuppressive Treatment Reveals the Dynamic Immune Characteristics

Frontiers in Immunology, 2021
Kidney transplantation is currently the first choice of treatment for various types of end-stage renal failure, but there are major limitations in the application of immunosuppressive protocols after kidney transplantation.
Yongguang Liu, Xiaoyou Liu, Song Zhou, Ruiquan Xu, Ruiquan Xu, Jianmin Hu, Guorong Liao, Jun Liao, Zefeng Guo, Yuzhu Li, Siqiang Yang, Shichao Li, Hua Chen, Ying Guo, Min Li, Lipei Fan, Liuyang Li, Ming Zhao, Ding Liu   +18 more
doaj   +1 more source

Synthetic N-Alkylated Iminosugars as New Potential Immunosuppressive Agents

, 2016
The new emerging immunosuppressive effects displayed by iminosugars have not been much investigated so far. Several new N-alkyl dideoxy iminoalditols were designed and synthesized to explore their immunosuppressive effects.
Jia Ye (6541), Xin-Shan Ye (1393843), Guan-Nan Wang (323894), Yulan Xiong (250746), Li-He Zhang (114202)   +4 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Synthetic Iminosugar Derivatives as New Potential Immunosuppressive Agents

, 2016
Several iminosugar derivatives were synthesized, and their effects on the secretion of IL-4 and IFN-γ from the mouse splenocytes were examined. The effects on membrane expression of other T cell-associated molecules (CD3, CD4, CD8) and B cell-associated ...
Xin-Shan Ye (1393843), Min Liu (45756), Guisheng Zhang (633478), Xiao-Lian Zhang (368806), Fang Sun (336111), Yuhang Wang (332111), Qin Li (36669), Li-He Zhang (114202)   +7 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Investigation and analysis of medication status in patients with uveitis

Yanke Xuebao
Objective: To evaluate medication use and prescribing patterns in patients with uveitis to guide rational clinical pharmacotherapy. Methods: In this retrospective study, prescription data for uveitis patients visiting the ophthalmology outpatient ...
WANG Jing, ZHANG Huizhi, SUN Huibin, HUANG Yingying, ZHANG Ying   +4 more
doaj   +1 more source