Efficacy and Safety of Glucocorticoid Monotherapy Versus the Combination of Glucocorticoid and Immunosuppressive Agents for Immunoglobulin G4-Related Disease: A Systematic Review and Meta-Analysis. [PDF]
Cureus, 2023 Alsalamah NI +5 more
europepmc +1 more source
PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites
Advanced Science, EarlyView.This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang +13 more
wiley +1 more source
Hepatitis C‐induced hepatocyte apoptosis following liver transplantation is enhanced by immunosuppressive agents [PDF]
, 2016 Eu Jin Lim +6 more
openalex +1 more source
Advanced Science, EarlyView.Glutamine deprivation triggers ACSL5 upregulation in tumor cells, sustaining their viability via dual metabolic rewiring programs. ACSL5 enhances glycolysis by relieving p53's inhibition of PGAM1 while also sustaining mitochondrial respiration and TCA cycle flux through promoting IDH2 dimerization.
Shuai Tian +11 more
wiley +1 more source
Long-Term Use of Immunosuppressive Agents Increased the Risk of Fractures in Patients with Autoimmune Diseases: An 18-Year Population-Based Cohort Study. [PDF]
Biomedicines, 2023 Kao FC +5 more
europepmc +1 more source
Advanced Science, EarlyView.An autologous whole‐tumor‐cell vaccine (rWTC‐MBTA) is evaluated in murine CNS lymphoma. Subcutaneous vaccination activates dendritic cells, broadens T‐cell priming, and drives lymphocyte trafficking to brain tumors, producing durable tumor control. Longitudinal bioluminescence and adoptive‐transfer assays verify CNS engagement. Combination with anti‐PD‐
Yaping Zhang +10 more
wiley +1 more source
Immunogenicity and safety of SARS-CoV-2 vaccine with immunosuppressive agents. [PDF]
Pediatr Int, 2022 Kamei K +7 more
europepmc +1 more source
Advanced Science, EarlyView.Elemene increases SPP expression by competitively binding with miR‐130a‐5p to suppress SPP mRNA degradation. This led to more antigen/MHC‐I complexes being expressed on the cell surface, which consequently facilitated the recognition and killing of HCC cells by CTLs and enhancing the antitumor immune efficacy of anti‐PD‐1.
Menglan Wang +18 more
wiley +1 more source
Novel amides of mycophenolic acid and some heterocyclic derivatives as immunosuppressive agents. [PDF]
J Enzyme Inhib Med Chem, 2022 Walczak JM +6 more
europepmc +1 more source
Advanced Science, EarlyView.Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong +6 more
wiley +1 more source