Effects of combined administration of FK 506 and the purine biosynthesis inhibitors mizoribine or mycophenolic acid on lymphocyte DNA synthesis and T cell activation molecule expression in human mixed lymphocyte cultures [PDF]
, 1993 Our objective was to obtain new information on the in vitro antilymphocytic action of the cytokine synthesis inhibitor FK 506 and the purine biosynthesis inhibitors mycophenolic acid (MPA; the active moiety of RS61443) and mizoribine (MZB) when used ...
A. Zeevi +34 more
core +1 more source
Cytokine release syndrome in COVID-19 patients, a new scenario for an old concern. The fragile balance between infections and autoimmunity [PDF]
, 2020 On 7 January 2020, researchers isolated and sequenced in China from patients with severe pneumonitis a novel coronavirus, then called SARS-CoV-2, which rapidly spread worldwide, becoming a global health emergency.
Diamanti, A. P. +4 more
core +2 more sources
Infectious Diseases Associated With Renal Homotransplantation: I. Incidence, Types, and Predisposing Factors [PDF]
, 1964 Infectious diseases occurred in 26 of 30 renal homotransplantation patients and contributed to eight of the 12 deaths in this series. There were 52 infections, 17 occurring before and 35 after transplantation.
Marchioro, TL +3 more
core +1 more source
Nonimmunologic targets of immunosuppressive agents in podocytes
Kidney Research and Clinical Practice, 2015 Proteinuria is a characteristic finding in glomerular diseases and is closely associated with renal outcomes. In addition, therapeutic interventions that reduce proteinuria improve renal prognosis.
Tae-Hyun Yoo, Alessia Fornoni
doaj +1 more source
Imunossupressores na Dermatologia Immunosuppressive agents in Dermatology
Anais Brasileiros de Dermatologia, 2010 Os imunossupressores são drogas que agem na divisão celular e têm propriedades anti-inflamatórias. Sendo assim, são essencialmente prescritos na prevenção de rejeição de transplantes e no tratamento das doenças autoimunes e inflamatórias crônicas, que ...
Aline Lopes Bressan +3 more
doaj +1 more source
Chinese Journal of Traumatology, 2021 Purpose: There were 10%–30% of patients with adult-onset septic arthritis (SA) exhibiting sterile synovial fluid (SF), and the uncertainty in the determining diagnosis of these patients posed a challenge in management.
Sandeep K. Nema +3 more
doaj +1 more source
TCD4pos lymphocytosis in rheumatoid and psoriatic arthritis patients following TNFα blocking agents [PDF]
, 2017 BACKGROUND: Lymphocyte expansion and true lymphocytosis are commonly observed in the everyday clinical practice. The meaning of such phenomenon is often poorly understood so that discrimination between benign and malignant lymphocytosis remains ...
Amodeo, Rachele +11 more
core +1 more source
Baseline use of hydroxychloroquine or immunosuppressive drugs and the risk of coronavirus disease 2019 [PDF]
The Korean Journal of Internal Medicine, 2022 Background/Aims The preventive role of hydroxychloroquine (HCQ) on coronavirus disease 2019 (COVID-19) remains unclear. The aim of this study was to examine the effects of HCQ and other immunosuppressive drugs on the incidence of COVID-19.
Ji-Won Kim +5 more
doaj +1 more source
What have we learned about primary liver transplantation under tacrolimus immunosuppression? - Long-term follow-up of the first 1000 patients [PDF]
, 1999 Objective: To summarize the long-term efficacy and safety of tacrolimus in orthotopic liver transplant (OLT) recipients, as well as to examine the factors that influence long-term morbidity and mortality rates. Background: Tacrolimus (FK506, Prograf) was
Abu-Elmagd, K +6 more
core +2 more sources
Immune Response to Vaccination in Patients with Psoriasis Treated with Systemic Therapies
Vaccines, 2020 Psoriasis is a chronic inflammatory skin disease usually treated with immunomodulatory/immunosuppressive agents. The use of these agents has been associated with an increased susceptibility to infections.
Andrea Chiricozzi +3 more
doaj +1 more source