Results 41 to 50 of about 3,568,234 (327)

Clinical and laboratory profile in confirmed vs. suspected septic arthritis patients and its relevance in decision making: A comparative cross-sectional study

Chinese Journal of Traumatology, 2021
Purpose: There were 10%–30% of patients with adult-onset septic arthritis (SA) exhibiting sterile synovial fluid (SF), and the uncertainty in the determining diagnosis of these patients posed a challenge in management.
Sandeep K. Nema, Suman Kumar Basel, Jose Austine, Kiyana Mirza   +3 more
doaj   +1 more source

Immune Response to Vaccination in Patients with Psoriasis Treated with Systemic Therapies

Vaccines, 2020
Psoriasis is a chronic inflammatory skin disease usually treated with immunomodulatory/immunosuppressive agents. The use of these agents has been associated with an increased susceptibility to infections.
Andrea Chiricozzi, Paolo Gisondi, Francesco Bellinato, Giampiero Girolomoni   +3 more
doaj   +1 more source

Phaeohyphomycosis in renal transplantation: report of two cases [PDF]

Anais Brasileiros de Dermatologia, 2016
Phaeohyphomycosis is an infection caused by a filamentous fungus that contains pigment melanin in its cell wall. We report two cases caused by Exophiala sp.
Walmar Roncalli Pereira de Oliveira, Maria Fernanda Longo Borsato, Maria Luiza Ducati Dabronzo, Cyro Festa Neto, Larissa Aragão Rocha, Ricardo Spina Nunes   +5 more
doaj   +1 more source

Cardiovascular effects of immunosuppression agents

Frontiers in Cardiovascular Medicine, 2022
Immunosuppressive medications are widely used to treat patients with neoplasms, autoimmune conditions and solid organ transplants. Key drug classes, namely calcineurin inhibitors, mammalian target of rapamycin (mTOR) inhibitors, and purine synthesis ...
Aly Elezaby, Aly Elezaby, Ryan Dexheimer, Karim Sallam, Karim Sallam   +4 more
doaj   +1 more source

Baricitinib for atopic dermatitis patients who responded inadequately to dupilumab treatment: First daily practice results

JEADV Clinical Practice, 2022
Background Baricitinib is the first JAK inhibitor registered for the treatment of moderate‐to‐severe atopic dermatitis (AD). Efficacy and safety were shown in clinical trials, but daily practice data is sparse.
Linde deWijs, Corine Schreurs, Anne Schlösser, Tamar Nijsten, Dirk Jan Hijnen   +4 more
doaj   +1 more source

Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: cohort study

British medical journal, 2017
Objective To compare the risk of serious infections associated with use of systemic steroids, non-biologic agents, or tumor necrosis factor α (TNF) inhibitors in pregnancy. Design Observational cohort study. Setting Public (Medicaid, 2001-10) or private (
R. Desai, B. Bateman, K. Huybrechts, Elisabetta Patorno, S. Hernández-Díaz, Yoonyoung Park, Sara Z Dejene, J. Cohen, H. Mogun, Seoyoung C. Kim   +9 more
semanticscholar   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Immunogenicity of pneumococcal vaccines in comorbid autoimmune and chronic respiratory diseases

Human Vaccines & Immunotherapeutics, 2019
Streptococcus pneumoniae causes pneumonia, meningitis, otitis media, and bacteremia. The mortality and morbidity of invasive pneumococcal disease are high among adults aged >65 years or those with underlying chronic or immunosuppressive conditions.
Koji Kuronuma, Hiroki Takahashi
doaj   +1 more source

CAR-T cell-mediated depletion of immunosuppressive tumor-associated macrophages promotes endogenous antitumor immunity and augments adoptive immunotherapy

Nature Communications, 2021
The immunosuppressive tumor microenvironment (TME) represents a major barrier for effective immunotherapy. Tumor-associated macrophages (TAMs) are highly heterogeneous and plastic cell components of the TME which can either promote tumor progression (M2 ...
A. Rodríguez-García, Rachel C. Lynn, M. Poussin, Monika A. Eiva, Lauren Shaw, Roddy S. O’Connor, Nicholas G. Minutolo, Victoria Casado-Medrano, Gonzalo Lopez, T. Matsuyama, D. Powell   +10 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source