Results 91 to 100 of about 119,989 (312)

A Universal Biomimetic Approach for Making Artificial Antigen‐Presenting Cells for T Cell Activation

Advanced Functional Materials, EarlyView.
This study shows a biomimetic silica microcapsule (SMC) fabrication method under mild conditions for making artificial antigen‐presenting cells (aAPCs). Inspired by marine biomineralization, peptide‐mediated biosilicification enables silica shell formation on emulsion templates. The resulting SMCs possess a core–shell structure, controlled fluorescence
Fei Hou, Supun Ranaweera, Xiangke Li, Ruirui Qiao, Yue Hui, Chun‐Xia Zhao   +5 more
wiley   +1 more source

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells [PDF]

, 2013
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
A Banerjee, AC Mullen, AM Intlekofer, AM Intlekofer, AM Intlekofer, B Lu, Binfeng Lu, CS Hinrichs, EL Pearce, F Pages, F Sallusto, Gang Li, GM Lord, Hong-Rui Wang, HZ Qui, I Atreya, JT Chang, K Kato, L Gattinoni, L Gattinoni, LJ Chen, M Wiesel, MA Paley, ME Pipkin, Mehrdad Matloubian, N Takemoto, NP Restifo, NS Joshi, Qianting Yang, SJ Szabo, WW Overwijk, X Zhou, Xinchun Chen, Xueguang Zhang, Y Zhang, Y Zhu, Yibei Zhu   +36 more
core   +3 more sources

Parameter estimation and treatment optimization in a stochastic model for immunotherapy of cancer [PDF]

arXiv, 2018
Adoptive Cell Transfer therapy of cancer is currently in full development and mathematical modeling is playing a critical role in this area. We study a stochastic model developed by Baar et al. in 2015 for modeling immunotherapy against melanoma skin cancer.
arxiv  

Label-free Raman spectroscopy and machine learning enables sensitive evaluation of differential response to immunotherapy [PDF]

arXiv, 2020
Cancer immunotherapy provides durable clinical benefit in only a small fraction of patients, particularly due to a lack of reliable biomarkers for accurate prediction of treatment outcomes and evaluation of response. Here, we demonstrate the first application of label-free Raman spectroscopy for elucidating biochemical changes induced by immunotherapy ...
arxiv  

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy. [PDF]

, 2018
Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a ...
Almeida, Neil D, Chuntova, Pavlina, Downey, Kira M, Hegde, Bindu, Okada, Hideho   +4 more
core  

Immunocompetent murine models for the study of glioblastoma immunotherapy. [PDF]

, 2014
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in ...
Bloch, Orin, Clark, Aaron J, Fakurnejad, Shayan, Ivan, Michael E, James, Charles D, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +9 more
core   +2 more sources

CD34 selected alloPBSCT and adoptive immunotherapy [PDF]

Bone Marrow Transplantation, 2000
To circumvent aGVHD in the early phase after allogeneic stem cell transplantation but to provide GVL activity later on, we performed alloPBSCT with CD34+ selected grafts followed by delayed add-back of CD3+ T cells. Ten consecutive patients having an HLA-identical sibling donor were enrolled on to this trial. Four patients were in first CR of high-risk
T Fietz, Eckhard Thiel, H. Schrezenmeier, W. U. Knauf   +3 more
openaire   +3 more sources

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Immune-mediated mechanisms influencing the efficacy of anticancer therapies [PDF]

, 2015
Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not only determined by their direct effects on cancer cells but also by off ...
Acharyya, Affara, Ahn, Ahn, Albanesi, Alizadeh, Anders, Andreu, Apetoh, Azab, Balachandran, Bald, Begg, Borg, Bos, Broz, Bruchard, Burnette, Casares, Cavnar, Chabner, Chao, Chung, Ciampricotti, Clynes, Coffelt, Cooper, Dankort, De Palma, De Palma, De Palma, De Palma, De Palma, de Visser, de Visser, Demaria, DeNardo, DeNardo, Deng, Deng, Derksen, Devaud, DeVita, Di Maio, Di Mitri, Diaz-Montero, Dijkgraaf, Dirkx, Dranoff, Du, DuPage, DuPage, Engelhardt, Ferrari de Andrade, Finke, Fischer, Francia, Fridlender, Gabrilovich, Gabrusiewicz, Ganesan, Garbe, Germano, Ghiringhelli, Ghiringhelli, Goodman, Grugan, Guerin, Guerriero, Gupta, Guy, Guy, Hagerling, Hamid, Han, Hanahan, Hanahan, Hanna, Hannesdottir, Herbst, Highfill, Ho, Hodi, Houthuijzen, Huang, Imai, Jiang, Kanterman, Karin E. de Visser, Kioi, Kitamura, Klug, Knight, Ko, Kodumudi, Kowanetz, Koya, Kozin, Krumbhaar, Landsberg, Le, Ledford, Lee, Lesterhuis, Li, Liauw, Lin, Lin, Liu, Lutsiak, Ma, Ma, Manning, Mantovani, Maroulakou, Matsumura, Mattarollo, Mazzieri, Minard-Colin, Mitchem, Mokyr, Muller, Muller, Munoz, Murdoch, Nakasone, Nefedova, Noh, North, Noy, Ojalvo, Olive, Pahler, Pander, Pardoll, Park, Paulus, Pienta, Pollizzi, Porembka, Powell, Powles, Priceman, Pucci, Pyonteck, Qian, Quail, Rakhra, Ramakrishnan, Reits, Ries, Robert, Robert, Robert, Rolny, Ruffell, Sahu, Sandhu, Savage, Schioppa, Seth B. Coffelt, Sevko, Shevchenko, Shojaei, Shojaei, Shojaei, Shree, Shrimali, Simpson, Singh, Singh, Singh, Sistigu, Smith, Snyder, Sommer, Srivastava, Stanley, Stockmann, Straussman, Suzuki, Suzuki, Swierczak, Takeshima, Talmadge, Taskinen, Terme, Toso, Tumeh, Ugel, Vanneman, Verbrugge, Vincent, Walter, Wang, Wang, Welford, Wilmott, Wu, Wu, Xu, Xue, Yang, Youn, Zhang, Zhang, Zhu   +206 more
core   +1 more source