Results 101 to 110 of about 327,034 (336)

Biomaterial-based ligand presentation to induce notch signaling in vitro [PDF]

, 2013
T cell adoptive transfer is an important procedure in immunotherapy. In immunocompromised patients, T cells may need to be developed from stem cells, requiring the induction of Notch signaling events responsible for native T cell differentiation in the ...
Mehta, Naveen
core   +1 more source

Transducer Materials Mediated Deep Brain Stimulation in Neurological Disorders

Advanced Functional Materials, EarlyView.
This review discusses advanced transducer materials for improving deep brain stimulation (DBS) in neurological disorders. These materials respond to light, ultrasound, or magnetic fields, enabling precise, less invasive neuromodulation. Their stimulus‐responsive properties enhance neural control and adaptive therapy, paving the way for next‐generation ...
Di Zhao, Zhengyang Cao, Guangjun Zhong, Limin Shi, Junxia Xie, Jianhua Hao   +5 more
wiley   +1 more source

CD34 selected alloPBSCT and adoptive immunotherapy [PDF]

Bone Marrow Transplantation, 2000
To circumvent aGVHD in the early phase after allogeneic stem cell transplantation but to provide GVL activity later on, we performed alloPBSCT with CD34+ selected grafts followed by delayed add-back of CD3+ T cells. Ten consecutive patients having an HLA-identical sibling donor were enrolled on to this trial. Four patients were in first CR of high-risk
T Fietz, Eckhard Thiel, H. Schrezenmeier, W. U. Knauf   +3 more
openaire   +3 more sources

DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models

Nature Communications, 2018
Adoptive T-cell therapy is a promising therapeutic approach for cancer patients. The use of allogeneic T-cell grafts will improve its applicability and versatility provided that inherent allogeneic responses are controlled.
Yuki Kagoya, M. Nakatsugawa, Kayoko Saso, Tingxi Guo, M. Anczurowski, Chung-Hsi Wang, M. Butler, C. Arrowsmith, N. Hirano   +8 more
semanticscholar   +1 more source

Genetically Engineered T-Cells for Malignant Glioma: Overcoming the Barriers to Effective Immunotherapy. [PDF]

, 2018
Malignant gliomas carry a dismal prognosis. Conventional treatment using chemo- and radiotherapy has limited efficacy with adverse events. Therapy with genetically engineered T-cells, such as chimeric antigen receptor (CAR) T-cells, may represent a ...
Almeida, Neil D, Chuntova, Pavlina, Downey, Kira M, Hegde, Bindu, Okada, Hideho   +4 more
core  

T-Bet and Eomes Regulate the Balance between the Effector/Central Memory T Cells versus Memory Stem Like T Cells [PDF]

, 2013
Memory T cells are composed of effector, central, and memory stem cells. Previous studies have implicated that both T-bet and Eomes are involved in the generation of effector and central memory CD8 T cells.
A Banerjee, AC Mullen, AM Intlekofer, AM Intlekofer, AM Intlekofer, B Lu, Binfeng Lu, CS Hinrichs, EL Pearce, F Pages, F Sallusto, Gang Li, GM Lord, Hong-Rui Wang, HZ Qui, I Atreya, JT Chang, K Kato, L Gattinoni, L Gattinoni, LJ Chen, M Wiesel, MA Paley, ME Pipkin, Mehrdad Matloubian, N Takemoto, NP Restifo, NS Joshi, Qianting Yang, SJ Szabo, WW Overwijk, X Zhou, Xinchun Chen, Xueguang Zhang, Y Zhang, Y Zhu, Yibei Zhu   +36 more
core   +3 more sources

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Immunocompetent murine models for the study of glioblastoma immunotherapy. [PDF]

, 2014
Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in ...
Bloch, Orin, Clark, Aaron J, Fakurnejad, Shayan, Ivan, Michael E, James, Charles D, Oh, Taemin, Parsa, Andrew T, Safaee, Michael, Sayegh, Eli T, Sun, Matthew Z   +9 more
core   +2 more sources

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

1080 Immunotherapy: ADOPTIVE T CELL IMMUNOTHERAPY FOR SARS-COV-2

Cytotherapy, 2023
A. Henden, K. Lineburg, L. Le Texier, J. Raju, P. Crooks, E. Wright, A. Scott, M. Neller, S. Tey, Rekha Khanna, C. Smith   +10 more
semanticscholar   +1 more source