Results 111 to 120 of about 327,034 (336)

Inhibition of AKT signaling uncouples T cell differentiation from expansion for receptor-engineered adoptive immunotherapy.

JCI Insight, 2017
Adoptive immunotherapies using T cells genetically redirected with a chimeric antigen receptor (CAR) or T cell receptor (TCR) are entering mainstream clinical practice. Despite encouraging results, some patients do not respond to current therapies.
C. Klebanoff, Joseph G Crompton, A. Leonardi, Tori N. Yamamoto, Smita S Chandran, R. Eil, M. Sukumar, S. Vodnala, Jinhui Hu, Yun Ji, D. Clever, Mary A. Black, Devikala Gurusamy, M. Kruhlak, P. Jin, D. Stroncek, L. Gattinoni, S. Feldman, N. Restifo   +18 more
semanticscholar   +1 more source

Study protocol for THINK : a multinational open-label phase I study to assess the safety and clinical activity of multiple administrations of NKR-2 in patients with different metastatic tumour types [PDF]

, 2017
Introduction: NKR-2 are autologous T cells genetically modified to express a chimeric antigen receptor (CAR) comprising a fusion of the natural killer group 2D (NKG2D) receptor with the CD3 zeta signalling domain, which associates with the adaptor ...
Aftimos, Philippe, Awada, Ahmad, Brayer, Jason B, Catala, Gaetan, Davila, Marco L, Gilham, David E, Hendlisz, Alain, Kerre, Tessa, Lehmann, Frederic F, Lonez, Caroline, Machiels, Jean-Pascal H, Odunsi, Kunle, Piette, Fanny, Sallman, David A, Van den Neste, Eric, Verma, Bikash   +15 more
core   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Immunotherapy in Cervical and Endometrial Cancer: Current Landscape and Future Directions

Life
Gynecological cancers pose a significant burden on women’s health worldwide, necessitating innovative treatment approaches. Immunotherapy has emerged as a promising strategy, harnessing the body’s immune system to combat cancer.
Dimitrios Stefanoudakis, Evaggelia Karopoulou, Alkis Matsas, Georgia Anna Katsampoula, Ermioni Tsarna, Eleni Stamoula, Panagiotis Christopoulos   +6 more
doaj   +1 more source

Oncologic Emergencies: Immune-Based Cancer Therapies and Complications [PDF]

, 2020
Cancer therapies have undergone several recent advancements. Current cancer treatments include immune-based therapies comprised of checkpoint inhibitors, and adoptive immunotherapy; each treatment has the potential for complications that differ from ...
Brém, Elizabeth, Koyfman, Alex, Long, Brit Jeffrey   +2 more
core  

Immune-mediated mechanisms influencing the efficacy of anticancer therapies [PDF]

, 2015
Conventional anticancer therapies, such as chemotherapy, radiotherapy, and targeted therapy, are designed to kill cancer cells. However, the efficacy of anticancer therapies is not only determined by their direct effects on cancer cells but also by off ...
Acharyya, Affara, Ahn, Ahn, Albanesi, Alizadeh, Anders, Andreu, Apetoh, Azab, Balachandran, Bald, Begg, Borg, Bos, Broz, Bruchard, Burnette, Casares, Cavnar, Chabner, Chao, Chung, Ciampricotti, Clynes, Coffelt, Cooper, Dankort, De Palma, De Palma, De Palma, De Palma, De Palma, de Visser, de Visser, Demaria, DeNardo, DeNardo, Deng, Deng, Derksen, Devaud, DeVita, Di Maio, Di Mitri, Diaz-Montero, Dijkgraaf, Dirkx, Dranoff, Du, DuPage, DuPage, Engelhardt, Ferrari de Andrade, Finke, Fischer, Francia, Fridlender, Gabrilovich, Gabrusiewicz, Ganesan, Garbe, Germano, Ghiringhelli, Ghiringhelli, Goodman, Grugan, Guerin, Guerriero, Gupta, Guy, Guy, Hagerling, Hamid, Han, Hanahan, Hanahan, Hanna, Hannesdottir, Herbst, Highfill, Ho, Hodi, Houthuijzen, Huang, Imai, Jiang, Kanterman, Karin E. de Visser, Kioi, Kitamura, Klug, Knight, Ko, Kodumudi, Kowanetz, Koya, Kozin, Krumbhaar, Landsberg, Le, Ledford, Lee, Lesterhuis, Li, Liauw, Lin, Lin, Liu, Lutsiak, Ma, Ma, Manning, Mantovani, Maroulakou, Matsumura, Mattarollo, Mazzieri, Minard-Colin, Mitchem, Mokyr, Muller, Muller, Munoz, Murdoch, Nakasone, Nefedova, Noh, North, Noy, Ojalvo, Olive, Pahler, Pander, Pardoll, Park, Paulus, Pienta, Pollizzi, Porembka, Powell, Powles, Priceman, Pucci, Pyonteck, Qian, Quail, Rakhra, Ramakrishnan, Reits, Ries, Robert, Robert, Robert, Rolny, Ruffell, Sahu, Sandhu, Savage, Schioppa, Seth B. Coffelt, Sevko, Shevchenko, Shojaei, Shojaei, Shojaei, Shree, Shrimali, Simpson, Singh, Singh, Singh, Sistigu, Smith, Snyder, Sommer, Srivastava, Stanley, Stockmann, Straussman, Suzuki, Suzuki, Swierczak, Takeshima, Talmadge, Taskinen, Terme, Toso, Tumeh, Ugel, Vanneman, Verbrugge, Vincent, Walter, Wang, Wang, Welford, Wilmott, Wu, Wu, Xu, Xue, Yang, Youn, Zhang, Zhang, Zhu   +206 more
core   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Notch-mediated conversion of activated T cells into stem cell memory-like T cells for adoptive immunotherapy

Nature Communications, 2017
Adoptive T-cell immunotherapy is a promising approach to cancer therapy. Stem cell memory T (TSCM) cells have been proposed as a class of long-lived and highly proliferative memory T cells.
T. Kondo, R. Morita, Yuumi Okuzono, Hiroko Nakatsukasa, T. Sekiya, S. Chikuma, T. Shichita, M. Kanamori, M. Kubo, K. Koga, T. Miyazaki, Y. Kassai, A. Yoshimura   +12 more
semanticscholar   +1 more source

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy? [PDF]

, 2019
No standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors.
Alessandra Cassano, Apte, Bill, Blom, Brigida Anna Maiorano, De Vries, Durie, Emilio Bria, Ericsson, Ernesto Rossi, Giampaolo Tortora, Gianluigi Petrone, Giovanni Schinzari, Guido Rindi, Ilaria Grazia Zizzari, Lagouros, Makitie, Maria Antonietta Blasi, Maria Grazia Sammarco, Marianna Nuti, Monica Maria Pagliara, Shaw, Sohn, Vincenzo Fiorentino, Whelchel   +24 more
core   +1 more source

Progress of Immune‐Inducible Biomaterials for Post‐Ablation Cancers

Advanced Healthcare Materials, EarlyView.
The presence of residual tumors after ablative therapies poses a significant challenge, generally resulting in recurrence and metastases. This review offers a concise overview of immune‐inducible biomaterials from the perspective of the cancer‐immunity cycle, and how they enhance antitumor immunity through diverse mechanisms following ablative ...
Shuangshuang Zhao, Zheng Zhang, Xincai Wu, Yanwei Chen, Wenjun Li, Jiayan Bao, Xin Zhang, Baoding Chen   +7 more
wiley   +1 more source