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Adoptive immunotherapy of urologic tumors
1989The treatment of humans with advanced cancer represents a major therapeutic challenge. One approach to treating metastatic cancer is immunotherapy, which can be classified into active and passive categories. Active immunotherapy refers to the immunization of the tumor-bearing host with materials that attempt to induce in the host a state of immune ...
A, Belldegrun, S A, Rosenberg
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An artificial solution for adoptive immunotherapy
Trends in Biotechnology, 2003Abstract Adoptive immunotherapy is a promising strategy in the battle against cancer and infectious diseases and the recently developed artificial antigen-presenting cell (aAPC) overcomes several obstacles for this therapy. The aAPC recapitulates the natural in vivo antigen-presenting cell (APC)–T cell interactions by coupling human leukocyte ...
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CASE FOR ADOPTIVE IMMUNOTHERAPY IN CANCER
The Lancet, 1982Patients with normal immune systems may be unable to mount effective defences against solid tumours because of (1) the generation of suppressor T cells in the low zone tolerance response elicited by the low concentrations of antigen furnished by slow growing solid tumours; (2) the ineffectiveness of the cytolytic T-cell response when the tumour cell ...
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Adoptive Immunotherapy in Chimeras
2003Depletion of T-cells from the marrow by treatment with absorbed antithymocyte globulin (ATG) prevents GVHD in DLA-identical littermates and transfusion of donor lymphocytes on days 1 and 2, 21 and 22 induces fatal GVHD. However transfusion on days 61 and 62 dose not produce GVHD and the animals survive.
H.-J. Kolb +9 more
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