Results 281 to 290 of about 867,189 (360)

Autoantigen mRNA‐LNP Vaccination Drives Therapeutic Efficacy in Preclinical Models for Autoimmunity

Advanced Science, EarlyView.
Systemic and intramuscular delivery of autoantigen mRNA via lipid nanoparticles reprograms antigen‐presenting cells toward a mature, homeostatic state, driving antigen‐specific T cell exhaustion and providing therapeutic efficacy across autoimmune disease models.
Paulien Baeten, Karen Beets, Tessa Schalley, Janne Verreycken, Gayel Duran, Daphne Lintsen, Lisa Schuetz, Xue Zhong, Rinke Nieuwschepen, Melissa Schepers, Brecht Moonen, Jeroen Bogie, Jana Van Broeckhoven, Carlo Heirman, Jurgen Van den Heuvel, Bart Vanderborght, Ismael Varela, Roxanne Nouille, Lotte Jacobs, Jessica Filtjens, Sabah Kasmi, Elise Seynaeve, Veronica Mavrovouna, Jana De Vrieze, Michael A. Brehm, Sandra Maréchal, Sophie Janssens, Florence Lambolez, Niels Hellings, Stefaan De Koker, Bieke Broux   +30 more
wiley   +1 more source

Clinical evaluation of low-dose radiation therapy for immunotherapy resistance in advanced non-small cell lung cancer. [PDF]

Transl Cancer Res
Fu DJ, Daleng GW, Wang WJ, Gao JL, Wuyun GW, Han YL, Tian D, Deng SQ, Li QF.   +8 more
europepmc   +1 more source

Targeting p21‐High Senescent Kupffer Cells Nanotherapeutically Potentiates Antitumor Immunity in Advanced Hepatocellular Carcinoma with Portal Vein Tumor Thrombus

Advanced Science, EarlyView.
Schematic illustration of a biomimetic SKEV@AAV platform targeting p21‐high senescent Kupffer cells (sKCs) in hepatocellular carcinoma (HCC) with portal vein tumor thrombus (PVTT). p21‐high sKCs accumulate in the PVTT microenvironment and establish an immunosuppressive, SASP‐rich environment that facilitates tumor cell proliferation and immune evasion.
Na Ta, Shuyi Wang, Boyan Zhang, Ning Liu, Yingchen Han, Aoran Liu, Ying Xu, Tingsong Chen, Ye Zhang, Qiuhua Luo, Tao Han   +10 more
wiley   +1 more source

Extended-Release Immunotherapy-Eluting Embolics. [PDF]

Cancers (Basel)
Mohammad IS, Patel AK, Rosen ST, Kortylewski M, Kessler J, Ressler J, Lall C, Guerra C, Chiang J, Boas FE.   +9 more
europepmc   +1 more source

Prognostic Value of the Prognostic Nutritional Index in Patients with Metastatic Melanoma. [PDF]

J Cancer
Sahbazlar M, Akar H, Erdogan AP, Ekinci F.   +3 more
europepmc   +1 more source

Correction: NT-I7, a novel long-acting interleukin-7, promotes anti-PD-1 efficacy in an autologous humanized melanoma model

Scientific Reports
Yee Peng Phoon, Alexandra A. Wolfarth, Pauline Funchain, Jennifer S. Ko, Donghoon Choi, Eliska Dedkova, Daniela Duarte Bateman, Jessica Corvin, Jan J. Melenhorst, Brian R. Gastman   +9 more
doaj   +1 more source

Adjuvant and neoadjuvant therapies in HCC: Time to go perioperative? [PDF]

iScience
Pantzios S, Germanidis G, Elefsiniotis I.   +2 more
europepmc   +1 more source