Results 171 to 180 of about 37,251,550 (358)
Historical changes in the Causal Effect Networks of compound hot and dry extremes in central Europe
Communications Earth & EnvironmentChanges in hot and dry extremes in central Europe have been attributed to atmospheric circulation anomalies and land-atmosphere interactions. However, the strength of the underlying causal links and their historical trends have not been quantified. Here,
Yinglin Tian +6 more
doaj +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
A review of the matching process for the impact analysis of the HMP Peterborough Social Impact Bond [PDF]
, 2017 In 2010, the world’s first Social Impact Bond (SIB) was launched at Peterborough Prison. It was used to fund an intervention – ‘The One Service’ – aimed at reducing the reoffending among prisoners discharged after serving a sentence of less than 12 ...
Anders, J., Dorsett, R.
core
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Environmental Research LettersCircumglobal teleconnections from wave-like patterns in the mid-latitude jets can lead to synchronized weather extremes in the mid-latitudes of Northern and Southern hemispheres.
Kai Kornhuber +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Resourcing social enterprises: approaches and challenges [PDF]
, 2015 This is the second publication from the Bankwest Foundation Social Impact Series and includes preliminary findings from the Supporting Development and Growth in the Community Sector in Western Australia research program.
Sharine Barth, Jo Barraket, Chris Mason
core
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
On the Impact of Technology on University Analysis
Dynamic Mathematics Systems provide a way to make mathematical objects such as sequences and functions accessible to students, and therefore one may hope that they can improve the learning even of advanced mathematics as taught in university-level analysis courses. During a course on analysis, students were given additional exercises with GeoGebra, and
openaire +2 more sources