Results 161 to 170 of about 65,026,818 (351)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Historical changes in the Causal Effect Networks of compound hot and dry extremes in central Europe
Communications Earth & EnvironmentChanges in hot and dry extremes in central Europe have been attributed to atmospheric circulation anomalies and land-atmosphere interactions. However, the strength of the underlying causal links and their historical trends have not been quantified. Here,
Yinglin Tian +6 more
doaj +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Annual IMPACT Report 2014: A report by the IMPACT Data Collection and Analysis Team, Part 1 [PDF]
, 2014 This is an annual report of Instruction Matters: Purdue Academic Course Transformation (IMPACT). IMPACT was created in 2010, and is a large collaborative initiative on the Purdue West Lafayette campus involving multiple key partners across campus ...
IMPACT Management Team +1 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Finnish Council of Regulatory Impact Analysis, Annual Review 2025
The Finnish Council of Regulatory Impact Analysis issues statements on the regulatory impact assessments of government proposals. Its work is based on the Guidelines for Drafting Government Proposals and the Guidelines for Impact Assessment in Law ...
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Annual IMPACT report 2017: A report by the IMPACT data collection and analysis team [PDF]
, 2017 This is the 2017 annual report of Instruction Matters: Purdue Academic Course Transformation (IMPACT). IMPACT was created in 2010, and is a large collaborative initiative on the Purdue West Lafayette campus involving multiple key partners across campus ...
IMPACT Management Team, +1 more
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Environmental Research LettersCircumglobal teleconnections from wave-like patterns in the mid-latitude jets can lead to synchronized weather extremes in the mid-latitudes of Northern and Southern hemispheres.
Kai Kornhuber +4 more
doaj +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
Impact: health and welfare division report 2003-2005
, 2006 IMPACT members gave a massive endorsement to the Sustaining Progress national deal in March 2003, when they backed it by 9-1 in a national bailout entitled all workers to pay increases worth a total of seven per cent in the first 18 months of the ...
IMPACT
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