Results 161 to 170 of about 37,251,550 (358)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Using Internal Evaluations to Measure Organizational Impact: A meta-analysis of Oxfam's women's empowerment projects [PDF]

, 2017
This paper presents the results of a meta-analysis examining the overall impact of women’s empowerment projects evaluated as part of Oxfam GB’s Effectiveness Reviews.
Lombardini, Simone, McCollum, Kristen
core  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Impact Assessment in the EU: The State of the Art and the Art of the State. CEPS Paperbacks. January 2006 [PDF]

, 2006
Policy-makers increasingly see impact assessment as the philosopher’s stone that will enhance the quality of EU legislation in the years to come, leading Europe back onto the Lisbon track.
Renda, Andrea
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Regulatory impact analysis: benchmarking - draft report [PDF]

, 2012
There is considerable scope to improve the way that regulations are developed and scrutinised by all governments, according to this draft report. In Regulatory Impact Analysis: Benchmarking - a report requested by COAG - the Productivity Commission ...

core  

Income and inequality pathways consistent with eradicating poverty

Environmental Research Letters
To investigate concurrent climate action and poverty eradication, we present combined income growth (GDP/capita) and domestic income inequality (measured as Gini coefficients) pathways that pursue (absolute and relative) poverty eradication reflecting ...
Jihoon Min, Bjoern Soergel, Jarmo S Kikstra, Johannes Koch, Bas van Ruijven   +4 more
doaj   +1 more source

Environmental risks and bank capital measures: A theoretical approach

International Review of Economics & Finance
This paper examines the integration of environmental risks into pillar I capital requirements through brown-penalising and green-supporting factors. Using a principal-agent approach with a Walsh-type contract, the model formalises how political pressures
Olli Castrén, Riccardo Russo
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source