Results 141 to 150 of about 65,026,818 (351)
Non-Linear Mean Impact Analysis [PDF]
, 2015 The interpretation and the validity of the results from linear regression rely on strong modeling assumptions (e.g. linearity of the conditional mean of Y given X1, ...,Xk) which are known not to be satisfied in many cases.
Scharpenberg, Martin
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Global ChallengesThe concept of sustainability has been shaped by the history of environmental problems and ecological crises, and the scientific value of studying the past has long been recognized.
Georg Feulner
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Finnish Council of Regulatory Impact Analysis, Annual Review 2023
The Council of Regulatory Impact Analysis issued a total of 24 statements on draft government proposals and Union communications in 2023. The Council assessed 14 draft government proposals and 10 Union communications. Draft government proposals and Union
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Exploring Process Aspects of Change Impact Analysis
, 2007 Change is inevitable in software development. During the entire lifecycle of a software system, from conception to retirement, things happen that require the system to be changed: the hardware and software environment changes, customer needs evolve,
Jönsson, Per
core
Impact methods to predict and assess contributions of technology (IMPACT): Final report [PDF]
, 2000 Metadata only recordThis report covers research done for the USAID Office of Agriculture and Food Security of the Center for Economic Growth and Agriculture (Global Bureau).
Texas A&M University
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source