Results 141 to 150 of about 37,251,550 (358)
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Soft systems methodology analysis for scoping in environmental impact statement in Israel [PDF]
, 1999 The current working paper will focus on Soft System Methodology (SSM) analysis of the process of issuing guidelines for Environmental Impact Statements (EIS) to developers in the Israeli context.
Haklay, M
core
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Peterborough social impact bond: final report on cohort 2 analysis [PDF]
, 2017 In 2010, the world’s first Social Impact Bond (SIB) was launched at Peterborough Prison. It was used to fund an intervention – ‘The One Service’ – aimed at reducing the reoffending among prisoners discharged after serving a sentence of less than 12 ...
Anders, J., Dorsett, R.
core
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
Environmental Research LettersSub-Saharan Africa is projected to be exposed to substantial climate change hazards, especially in its agricultural sector, so adaptation will be necessary to safeguard crop yields.
Lennart Jansen +2 more
doaj +1 more source
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Alternative to private finance of the welfare state: a global analysis of Social Impact Bond, Pay-for-Success and Development Impact Bond projects [PDF]
, 2015 Overview Social impact bond projects are the latest new ‘buy-now, pay later’, off-balance sheet schemes to increase private finance of public services and the welfare state, driven by austerity policies and neoliberal ideology.
Dexter Whitfield
core
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source