Results 131 to 140 of about 37,251,550 (358)

Change impact analysis of enterprise architectures

IRI -2005 IEEE International Conference on Information Reuse and Integration, Conf, 2005., 2005
An enterprise architecture is a high-level description intended to capture the vision of an enterprise integrating all its dimensions: organization structure, business processes, and infrastructure. Every single part of an enterprise is subject to change, and each change may have significant consequences within all domains of the enterprise.
F.S. de Boer (Frank), M.M. Bonsangue (Marcello), L.P.J. Groenewegen (Luuk), A. Stam, S. Stevens, L.W.N. van der Torre (Leon)   +5 more
openaire   +2 more sources

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Gender impact analysis and the taxation of retirement savings in Australia [PDF]

, 2015
Gender impact analysis of the tax transfer system makes gender issues in policies and budgets visible and enables their complexities to be revealed. By doing so, it facilitates the development of more equitable and efficient alternatives.
Austen, Siobhan, Sharp, R., Hodgson, Helen   +2 more
core  

Extreme weather events in early summer 2018 connected by a recurrent hemispheric wave-7 pattern

Environmental Research Letters, 2019
The summer of 2018 witnessed a number of extreme weather events such as heatwaves in North America, Western Europe and the Caspian Sea region, and rainfall extremes in South-East Europe and Japan that occurred near-simultaneously.
Kai Kornhuber, Scott Osprey, Dim Coumou, Stefan Petri, Vladimir Petoukhov, Stefan Rahmstorf, Lesley Gray   +6 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Measuring the impact of digital resources: the balanced value impact model [PDF]

, 2012
The Balanced Value Impact Model (BVI Model) draws evidence from a wide range of sources to provide a compelling account of the means of measuring the impact of digital resources and using evidence to advocate how change benefits people.

core  

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Impact Analysis via Reachability and Alias Analysis

, 2014
This work is concerned with localizing and analyzing the potential impact of changes to large-scale enterprise systems, and, in particular, how to incorporate reachability analysis and aliasing/pointer analysis to minimise false-positives and eliminate false-negatives.
Chen, Wen, Wassyng, Alan, Maibaum, Tom
openaire   +2 more sources