Results 61 to 70 of about 392,524 (314)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Real-Time Brillouin Microscopy for Linewidth Imaging of Protein Condensates in Living Cells
IEEE Photonics JournalWe propose a label-free, high-resolution approach to investigate pathological protein aggregation and aberrant phase behavior in living cells. Intracellular protein aggregates associated with neurodegenerative diseases are increasingly recognized for ...
C. Bartoli +14 more
doaj +1 more source
The Effect of Bubbles on Particle Migration in Non-Newtonian Fluids
Separations, 2021 The movement of the gas–liquid interface caused by the movement of the bubble position will have an impact on the starting conditions for particle migration.
Jie Shan, Xiaojun Zhou
doaj +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Impact and spreading of microdrops on homo- and heterogeneous solids: Modelling and benchmark simulations [PDF]
, 2011 This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
3rd Micro and Nano Flows Conference (MNF2011) +2 more
core
A constitutive model for analyzing martensite formation in austenitic steels deforming at high strain rates [PDF]
, 2006 This study presents a constitutive model for steels exhibiting SIMT, based on previous seminal works, and the corresponding methodology to estimate their parameters.
ZAERA, Ramon +5 more
core +5 more sources
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
A pressure impulse theory for hemispherical liquid impact problems
, 2017 Liquid impact problems for hemispherical fluid domain are considered. By using the concept of pressure impulse we show that the solution of the flow induced by the impact is reduced to the derivation of Laplace's equation in spherical coordinates with ...
Antkowiak, Arnaud +2 more
core +3 more sources
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines
FEBS Open Bio, EarlyView.Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart +7 more
wiley +1 more source