Results 71 to 80 of about 389,827 (297)

An efficient mixed variational reduced order model formulation for non-linear analyses of elastic shells [PDF]

, 2017
The Koiter-Newton method had recently demonstrated a superior performance for non-linear analyses of structures, compared to traditional path-following strategies.
Garcea, G., Leonetti, L., Liang, K., Magisano, D., Ruess, M.   +4 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Solid-phase partitioning and release-retention mechanisms of copper, lead, zinc and arsenic in soils impacted by artisanal and small-scale gold mining (ASGM) activities

Chemosphere, 2020
Artisanal and small-scale gold mining (ASGM) operations are major contributors to the Philippines' annual gold (Au) output (at least 60%). Unfortunately, these ASGM activities lacked adequate tailings management strategies, so contamination of the environment is prevalent.
Carlito Baltazar Tabelin, Marthias Silwamba, Florifern C. Paglinawan, Alissa Jane S. Mondejar, Ho Gia Duc, Vannie Joy Resabal, Einstine M. Opiso, Toshifumi Igarashi, Shingo Tomiyama, Mayumi Ito, Naoki Hiroyoshi, Mylah Villacorte-Tabelin   +11 more
openaire   +2 more sources

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Data from Ribociclib (LEE011): Mechanism of Action and Clinical Impact of This Selective Cyclin-Dependent Kinase 4/6 Inhibitor in Various Solid Tumors

, 2023
<div>Abstract<p>The cyclin D–cyclin-dependent kinase (CDK) 4/6–p16–retinoblastoma (Rb) pathway is commonly disrupted in cancer, leading to abnormal cell proliferation. Therapeutics targeting this pathway have demonstrated antitumor effects in preclinical and clinical studies.
William R. Sellers, Aditya Bardia, Debu Tripathy   +2 more
openaire   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Triple condensate halo from water droplets impacting on cold surfaces

, 2018
Understanding the dynamics in the deposition of water droplets onto solid surfaces is of importance from both fundamental and practical viewpoints. While the deposition of a water droplet onto a heated surface is extensively studied, the characteristics ...
Jin, Liwen, New, Tze How, Yang, Chun, Zhang, Hui, Zhao, Yugang, Zhu, Fangqi   +5 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Method for calculating the parameters of the rotary-impact mechanism

Омский научный вестник
Modern rotary-impact mechanisms for the destruction of solid and frozen soils have a bulky and complex design. The development of a method for improving the rotaryimpact mechanism construction allows solving the problem of reducing the energy intensity ...
L. A. Sladkova, D. I. Skripnikov
doaj   +1 more source