Results 121 to 130 of about 9,636,514 (304)
La evaluación de las revistas científicas
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2001 Anàlisi general dels paràmetres que s'han anat utilitzat tradicionalment per a l'avaluació de les revistes científiques, comentant la possibilitat d'aplicar-los a les revistes espanyoles i específicament, a les revistes de documentació, les quals són ...
Pérez Álvarez-Osorio, José Ramón
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Theory of Change (ToC): A Method for Impact Planning and Assessment
Theory of Change (ToC) is a formative, process-based evaluation method that is most often used to inform or improve project planning. This is a description of the framework based on scientific literature, in which you can learn about Theory of Change ...
Evaluating Societal Impact
core +1 more source
Impact of Alternative Fuels on IMO Indicators
GasesThis study provides a comprehensive analysis of the impact of different marine fuels such as heavy fuel oil (HFO), methane, methanol, ammonia, or hydrogen, on energy efficiency and pollutant emissions in maritime transport, using a combined application ...
José Miguel Mahía-Prados +2 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
L'avaluació de les revistes científiques
BiD: Textos Universitaris de Biblioteconomia i Documentació, 2001 Anàlisi general dels paràmetres que s'han anat utilitzat tradicionalment per a l'avaluació de les revistes científiques, comentant la possibilitat d'aplicar-los a les revistes espanyoles i específicament, a les revistes de documentació, les quals són ...
Pérez Álvarez-Osorio, José Ramón
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source