Results 101 to 110 of about 8,940,064 (208)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Dynamic responses of shallow foundations on saturated soil under impact loadings

Magazine of Civil Engineering
In civil engineering, there are many problems related to the transmission of pressure waves through the soil due to dynamic loads. The objective of this investigation is to research the dynamic soil properties.
Azad Hameed Rasheed, Balqees Abdulwahid Ahmed   +1 more
doaj   +1 more source

Experimental and Numerical Study on the Strain Behavior of Buried Pipelines Subjected to an Impact Load

Applied Sciences, 2019
Long-distance oil and gas pipelines are inevitably impacted by rockfalls during geologic hazards such as mud-rock flow and landslides, which have a serious effect on the safe operation of pipelines. In view of this, an experimental and numerical study on
Feifei Dong, Xuemeng Bie, Jiangping Tian, Xiangdong Xie, GuoFeng Du   +4 more
doaj   +1 more source

Impact Strategy Development: Workshops to Co-create your Strategy

This tool serves as a guide for conducting workshops that enable strategic planning within your school. These workshops provide a structured environment for refection and dialogue, which empowers participants to articulate their aspirations for societal ...
Evaluating Societal Impact
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Analysis of impact load on tubing and shock absorption during perforating

Open Physics, 2019
During the past few decades, the technologies of the higher-shot densities, larger perforating guns and tubing-conveyed perforation (TCP) combined well testing have been used widely used for well completions.
Deng Qiao, Zhang Hui, Li Jun, Hou Xuejun, Wang Hao   +4 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Induction motor load impact on power system eigenvalue sensitivity analysis

, 2009
Load modelling plays an important role in power system dynamic stability assessment. One of the widely used methods in assessing load model impact on system dynamic response is parametric sensitivity analysis.
Mishra, Y., Dong, Z.Y., Hill, D.J., Hill, D. J., Dong, Z. Y., Ma, J, Ma, J., Mishra, Y, Dong, ZY, Hill, DJ   +9 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source