Results 51 to 60 of about 499,828 (261)
, 2004 An experimental apparatus has been constructed to simulate the impact of an aircraft against a nuclear power plant. In order to test the equipment some preliminary tests were carried out with simple inexpensive missiles against a rigid steel plate target.
Kärnä, Tuomo +3 more
+5 more sources
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Evaluation of Steel Frame Equipped with the Replaceable Shear Link Made of Shape Memory Alloy under the Impact Load [PDF]
Journal of Rehabilitation in Civil EngineeringDespite their low stiffness, moment frames (MFs) are considered conventional lateral strength systems for low- and moderate-rise structures due to their ability to absorb energy and provide suitable ductility, along with architectural considerations.
Reza Kamgar +2 more
doaj +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Numerical Simulation on the Leakage-Induced Collapse of Segmental Tunnels
Applied SciencesSudden leakage during tunnel construction poses a great threat to the safety of the tunnel. There are relatively few studies on the mechanism of structural collapse induced by tunnel leakage, so it is difficult to propose effective control measures.
Qihao Sun +3 more
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Calibration Method of PFC3D Micro-Parameters under Impact Load
Applied SciencesMicro-parameter calibration is essential in constructing an accurate and reliable numerical model of particle discrete element PFC3D 6.0 software. Micro-parameter calibration is mainly accomplished according to the macro-parameters obtained from static ...
Zehua Zhang, Wenle Gao, Yuming Kou
doaj +1 more source