Results 91 to 100 of about 8,600,070 (262)
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
The Astronomical JournalOn 2023 May 20, a ∼3.7 m diameter asteroid entered Earth’s atmosphere over northwest Queensland, Australia, at 27.9 km s ^−1 and underwent catastrophic fragmentation at ∼29 km altitude, producing 1 of the 20 most energetic bolide events reported by NASA ...
Elizabeth A. Silber +21 more
doaj +1 more source
Determinants of change in the duration of ice phenomena on the Vistula River in Toruń
Journal of Hydrology and Hydromechanics, 2015 Winter season temperatures are becoming warmer. However, the transformation of the ice regime on the Vistula River in Toruń has also been affected by river engineering.
Pawłowski Bogusław
doaj +1 more source
Thinking About my Impact and Engagement: A Worksheet
What does making positive societal impact mean to you? How do you map current and potential partners and beneficiaries? How to align your work to their needs? This workshop package offers a brief printable worksheet with accompanying presentation slides,
Evaluating Societal Impact
core +1 more source
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Impact Strategy Development: Questions Bank and Interview Guide
The tool ‘Impact Strategy Development: Questions Bank and Interview Guide’ consists of (1) a three step interview guide and (2) an Excel file with a questions bank to use and tailor for your interviews or other methods for engaging with your community ...
Evaluating Societal Impact
core +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Hydrous Chondrites under Shock
The Astrophysical JournalWe examine the shock response of a chondrule-like multicomponent silicate melt enriched with 2 wt% H _2 O, representative of hydrous chondrites, using ab initio molecular dynamics.
Adrien Saurety, Razvan Caracas
doaj +1 more source
Impact Strategy Development: Discovering your Current Organisational Landscape
This tool guides the research process of discovering a school’s organisational impact landscape as one of the steps when developing an impact strategy.
Evaluating Societal Impact
core +1 more source
Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy
Molecular Oncology, EarlyView.LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir +9 more
wiley +1 more source