Results 81 to 90 of about 8,600,070 (262)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Building Impact Stories: An Inspirational Guide for Communicators

This guide is designed to assist (external) communication professionals in articulating the societal impact of university activities, projects and initiatives stemming from the university’s education, research and engagement core missions and the ...
Evaluating Societal Impact
core   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Impact Disruption of Bjurböle Porous Chondritic Projectile

The Planetary Science Journal
The ∼200 m s ^−1 impact of a single 400 kg Bjurböle L/LL ordinary chondrite meteorite onto sea ice resulted in the catastrophic disruption of the projectile.
Tomas Kohout, Maurizio Pajola, Assi-Johanna Soini, Alice Lucchetti, Arto Luttinen, Alexia Duchêne, Naomi Murdoch, Robert Luther, Nancy L. Chabot, Sabina D. Raducan, Paul Sánchez, Olivier S. Barnouin, Andrew S. Rivkin   +12 more
doaj   +1 more source

Productive Interactions (SIAMPI): A Method for Impact Assessment

This resource informs readers about the SIAMPI framework for impact assessment introduced by Spaapen and Van Drooge (2011), enriched with the experiences of the Evaluating Societal Impact team at EUR using the method in two case studies.
Evaluating Societal Impact
core   +1 more source

Experimental evidence of critical phenomena in structure-water impact

, 2001
The design of modem high-speed vessels makes clear that extreme care must be devoted to fluid-structure interaction problems. It is a matter of fact that dangerous impact phenomena occur in fast marine vehicles, leading to severe pressure load conditions
A. CIAPPI, R. MARIANI, CARCATERRA, Antonio   +2 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Atmospheric Loss during Giant Impacts: Mechanisms and Scaling of Near- and Far-field Loss

The Planetary Science Journal
The primary epoch of planetary accretion concludes with giant impacts—highly energetic collisions between protoplanets that can play a key role in shaping a planet’s inventory of volatile elements.
Matthew J. Roche, Simon J. Lock, Jingyao Dou, Philip J. Carter, Jacob A. Kegerreis, Zoë M. Leinhardt   +5 more
doaj   +1 more source

Proximity Lens on Structural Collaborations: A Method for Impact Assessment

This resource provides a description of ‘proximities’ in impact assessment, building on Boschma (2005) and Knoben & Oerlemans (2006). Proximity dimensions provide a lens to identify and highlight the conditions that enable successful cooperation and ...
Evaluating Societal Impact
core   +1 more source

Comparison of experimental and numerical sloshing loads in partially filled tanks [PDF]

, 2009
Sloshing phenomenon consists in the movement of liquids inside partially filled tanks, whichgenerates dynamic loads on the tank structure. Resulting impact pressures are of great importance in assessingstructural strength, and their correct evaluation ...
Temarel, Pandeli, A. Souto Iglesias, N Moirod, S. Brizzolara, M. Viviani, N. Moirod, S Brizzolara, Brizzolara, S., Chen, Y.G., Y. Chen, N. Couty, Y Chen, Savio, Luca, L Diebold, Brizzolara, Stefano, P Temarel, L. Savio, A Souto Iglesias, Chen, Y., P. Temarel, Souto Iglesias, Antonio, Viviani, M., S. Hoflack, M Viviani, Souto Iglesias, A., L Savio, Moirod, N., Chen, P., Couty, N., L. Diebold, Viviani, Michele, Temarel, P., Hoflack, S., N Couty, Savio, L., Diebold, L., S Hoflack, Hoflack S., Couty N., Temarel P., Souto Iglesias A., Chen Y., Diebold L., Moirod N.   +43 more
core   +1 more source