Results 81 to 90 of about 296,363 (265)

Mercury’s Lobate Scarps Reveal that Polygonal Impact Craters Form on Contractional Structures

The Planetary Science Journal
Analysis of polygonal impact craters (PICs) can be used to investigate the presence and orientations of subtle and/or buried faults and fractures across the solar system that may otherwise be unobservable in spacecraft images. Although this technique has
Chloe B. Beddingfield, Kelsey Crane, Christian Klimczak, Richard Cartwright   +3 more
doaj   +1 more source

Heterotropic regulation and negative homotropic cooperativity

FEBS Open Bio, EarlyView.
We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea, Francesco Angelucci, Federica Arnesano, Gianmarco Pascarella, Patrizio Di Micco, Andrea Bellelli   +5 more
wiley   +1 more source

Planetesimal Impact Vapor Plumes and Nebular Shocks Form Chondritic Mixtures

The Planetary Science Journal
The origin of chondrules and the chondritic sedimentary rocks that dominate the meteoritic record is a long-standing problem in planetary science. Here, we develop a physical model for the formation of chondritic mixtures as an outcome of vaporizing ...
Sarah T. Stewart, Simon J. Lock, Philip J. Carter, Erik J. Davies, Michail I. Petaev, Stein B. Jacobsen   +5 more
doaj   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Long‐Term Follow‐Up of Chemotherapy‐Associated Biological Aging in Women With Early Breast Cancer

Aging and Cancer, EarlyView.
Women threated with adjuvant chemotherapy for early breast cancer have sustained long‐term increase in p16INK4a,, a robust marker of cell senescence, suggesting a chemotherapy‐associated age acceleration. p16INK4a as well as other biomarkers may identify patients at greatest risk for senescence‐related diseases of aging.
Hyman B. Muss, Alexis C. Wardell, Allison M. Deal, Kirsten A. Nyrop, Allison Ross, Yara G. Abdou, Jeffrey D. Aldrich, Lisa A. Cary, E. Claire Dees, Katherine E. Reeder‐Hayes, Emily M. Ray, Natalia Mitin, Denis Tsygankov   +12 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Impact-generated Porosity Gradients Controlled Fluid Flow and Aqueous Alteration on the CM Parent Body

The Planetary Science Journal
We investigated the relationship between microporosity, impact deformation, and aqueous alteration in the CM chondrite Murchison using high-resolution (1.86 μ m/voxel) X-ray computed tomography (XCT) combined with a pressurized xenon gas infiltration ...
Romy D. Hanna, Richard A. Ketcham, Dave R. Edey, Guillaume Avice, Kelly Miller, Alan Whittington   +5 more
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Cavitating Bubbles in Condensing Gas as a Means of Forming Clumps, Chondrites, and Planetesimals

The Astrophysical Journal Letters
Vaporized metal, silicates, and ices on the verge of recondensing into solid or liquid particles appear in many contexts: behind shocks, in impact ejecta, and within the atmospheres and outflows of stars, disks, planets, and minor bodies.
E. Chiang
doaj   +1 more source