Results 61 to 70 of about 295,654 (265)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Penetration Law in Loose Granular Medium for the Chang’E 5 and Chang’E 6 Footpad

The Planetary Science Journal
This study investigates the penetration behavior of the footpads used in the Chang’e-5 (CE-5) and Chang’e-6 (CE-6) lunar probes when interacting with granular materials.
Diwen Duan, Xu Meng, Hai Liu, Haijing Lu, Jianhui Li   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Degradation Mechanisms and Efficiency of Heavily Cratered Regions on Ceres

The Planetary Science Journal
Ceres, the dwarf planet in the main asteroid belt, hosts heavily cratered surfaces where craters are continuously eroded, mainly due to impact bombardment, with a limited influence by nonimpact processes.
Reem Vitale, Masatoshi Hirabayashi
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Droplet impact phenomena in nanolithography [PDF]

, 2019
Extreme ultraviolet lithography (EUVL) is the next generation of photo-lithography technology used by the semiconductor industry for the manufacturing of integrated circuits. Fundamental understanding of the fluid dynamics inside this machine is crucial to optimize and stabilize the EUV light used in this machine.
openaire   +1 more source

Impact Disruption of Bjurböle Porous Chondritic Projectile

The Planetary Science Journal
The ∼200 m s ^−1 impact of a single 400 kg Bjurböle L/LL ordinary chondrite meteorite onto sea ice resulted in the catastrophic disruption of the projectile.
Tomas Kohout, Maurizio Pajola, Assi-Johanna Soini, Alice Lucchetti, Arto Luttinen, Alexia Duchêne, Naomi Murdoch, Robert Luther, Nancy L. Chabot, Sabina D. Raducan, Paul Sánchez, Olivier S. Barnouin, Andrew S. Rivkin   +12 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Atmospheric Loss during Giant Impacts: Mechanisms and Scaling of Near- and Far-field Loss

The Planetary Science Journal
The primary epoch of planetary accretion concludes with giant impacts—highly energetic collisions between protoplanets that can play a key role in shaping a planet’s inventory of volatile elements.
Matthew J. Roche, Simon J. Lock, Jingyao Dou, Philip J. Carter, Jacob A. Kegerreis, Zoë M. Leinhardt   +5 more
doaj   +1 more source