Results 41 to 50 of about 296,363 (265)
Impacts on Ocean Worlds Are Sufficiently Frequent and Energetic to Be of Astrobiological Importance
The Planetary Science JournalEvidence for the beneficial role of impacts in the creation of urable or habitable environments on Earth prompts the question of whether meteorite impacts could play a similar role at other potentially urable/habitable worlds like Enceladus, Europa, and ...
Shannon M. MacKenzie +14 more
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Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
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Large Impacts onto the Early Earth: Planetary Sterilization and Iron Delivery
The Planetary Science Journal, 2022 Late accretion onto the Hadean Earth included large impacts that could have influenced early habitability, either by sterilizing the planet or alternatively catalyzing the origin of life by delivering iron required to create a reducing environment ...
Robert I. Citron, Sarah T. Stewart
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Delivery of DART Impact Ejecta to Mars and Earth: Opportunity for Meteor Observations
The Planetary Science JournalNASA’s Double Asteroid Redirection Test (DART) and ESA’s Hera missions offer a unique opportunity to investigate the delivery of impact ejecta to other celestial bodies. We performed ejecta dynamical simulations using 3 million particles categorized into
Eloy Peña-Asensio +3 more
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Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
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Dimorphos’s Material Properties and Estimates of Crater Size from the DART Impact
The Planetary Science JournalOn 2022 September 26, the Double Asteroid Redirection Test (DART) spacecraft intentionally collided with Dimorphos, the moon of the binary asteroid system 65803 Didymos.
Angela M. Stickle +40 more
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Droplet impact phenomena in nanolithography [PDF]
, 2019 Extreme ultraviolet lithography (EUVL) is the next generation of photo-lithography technology used by the semiconductor industry for the manufacturing of integrated circuits. Fundamental understanding of the fluid dynamics inside this machine is crucial to optimize and stabilize the EUV light used in this machine.
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