Results 41 to 50 of about 295,654 (265)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The Impact Of Leadership And Followership: An Organizational Phenomena

open access: yesJournal of Applied Business Research (JABR), 2021
Although traditional research has viewed leadership and followership as separate functions, recent studies have acknowledged the importance of followership in both the effectiveness and development of leaders. Followership models have emerged suggesting that leaders cannot be effective without having experience as a follower and that leaders and ...
Jay W. Edwards, Andrew E. Honeycutt
openaire   +1 more source

Investigation of Different Cardboard Materials Under Impact Loads

open access: yesBioResources, 2023
Packaging materials, such as cardboard, must endure vigorous loads during handling and transport, which could lead to damage to the packaged goods. To ensure that the transported goods reach the consumer safely, a profound knowledge of the behavior of ...
Philipp Johst   +4 more
doaj   +2 more sources

Crater Equilibrium State Characterization given Crater Production from a Single Power Law

open access: yesThe Planetary Science Journal
We generalize the crater equilibrium concept, a terminal state on a cratered surface where the balance of crater production and erasure apparently limits the crater population from further growth. Assuming the crater production consists of a single power
Masatoshi Hirabayashi   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Interesting and Impactful Research: On Phenomena, Theory, and Writing [PDF]

open access: yesSSRN Electronic Journal, 2016
Interesting research is impactful. It can emerge from deep immersion in a phenomenon yielding a premise that refutes the assumption of the audience. Theory should follow rather than precede the immersion in a phenomenon to explain it simply. The best writing is short, simple, and idea packed.
openaire   +2 more sources

Martian Dynamo Change at ∼4.1 Ga: Evidence from the Magnetic Measurements of the Iota Crater

open access: yesThe Astrophysical Journal
The Martian dynamo evolution is critical for understanding Mars’s interior structure, thermal evolution, and climate change. It has been inferred to shut down at ∼4.1–4.0 Ga based on the magnetic signatures of large impact craters, but be present at ∼3.9
Kuixiang Zhang   +8 more
doaj   +1 more source

The Effects of Early Collisional Evolution on Amorphous Water Ice Bodies

open access: yesThe Planetary Science Journal, 2023
Conditions in the outer protoplanetary disk during solar system formation were thought to be favorable for the formation of amorphous water ice (AWI), a glassy phase of water ice.
Jordan K. Steckloff   +2 more
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates

open access: yesFEBS Letters, EarlyView.
Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino   +2 more
wiley   +1 more source

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