Results 51 to 60 of about 8,600,070 (262)
Martian Dynamo Change at ∼4.1 Ga: Evidence from the Magnetic Measurements of the Iota Crater
The Astrophysical JournalThe Martian dynamo evolution is critical for understanding Mars’s interior structure, thermal evolution, and climate change. It has been inferred to shut down at ∼4.1–4.0 Ga based on the magnetic signatures of large impact craters, but be present at ∼3.9
Kuixiang Zhang +8 more
doaj +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
The Effects of Early Collisional Evolution on Amorphous Water Ice Bodies
The Planetary Science Journal, 2023 Conditions in the outer protoplanetary disk during solar system formation were thought to be favorable for the formation of amorphous water ice (AWI), a glassy phase of water ice.
Jordan K. Steckloff +2 more
doaj +1 more source
FEBS Letters, EarlyView.Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Impacts on Ocean Worlds Are Sufficiently Frequent and Energetic to Be of Astrobiological Importance
The Planetary Science JournalEvidence for the beneficial role of impacts in the creation of urable or habitable environments on Earth prompts the question of whether meteorite impacts could play a similar role at other potentially urable/habitable worlds like Enceladus, Europa, and ...
Shannon M. MacKenzie +14 more
doaj +1 more source
The Impact Toolbox by the Evaluating Societal Impact project is a catalogue of tools and methods that helps university staff select resources for a structured approach to academic impact ambitions, activities and assessment.The collection draws upon a ...
Evaluating Societal Impact
core +1 more source
Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research
FEBS Letters, EarlyView.What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley +1 more source
This tool presents a selection of competences that are relevant for societal impact. The content is presented as a non-exhaustive list of competences that academics can develop for impact-oriented academic activities.
Evaluating Societal Impact
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source