Results 51 to 60 of about 296,363 (265)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Penetration Law in Loose Granular Medium for the Chang’E 5 and Chang’E 6 Footpad
The Planetary Science JournalThis study investigates the penetration behavior of the footpads used in the Chang’e-5 (CE-5) and Chang’e-6 (CE-6) lunar probes when interacting with granular materials.
Diwen Duan +4 more
doaj +1 more source
The impact of particle polydispersity on fluidization phenomena [PDF]
, 2020 Doctor of Philosophy (SCBE)
openaire +2 more sources
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Degradation Mechanisms and Efficiency of Heavily Cratered Regions on Ceres
The Planetary Science JournalCeres, the dwarf planet in the main asteroid belt, hosts heavily cratered surfaces where craters are continuously eroded, mainly due to impact bombardment, with a limited influence by nonimpact processes.
Reem Vitale, Masatoshi Hirabayashi
doaj +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Earth-based observations of impact phenomena [PDF]
International Astronomical Union Colloquium, 1996 Earth-based observations at near- and mid-infrared wavelengths were obtained for at least 15 of the SL9 impacts, ranging from the spectacular G, K and L events to the barely-detected N and V impacts. Although there were a few exceptions, most of the IR lightcurves fit a common pattern of one or two relatively faint precursor flashes, followed several ...
openaire +1 more source
Molecular Oncology, EarlyView.Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant +11 more
wiley +1 more source
Impact Disruption of Bjurböle Porous Chondritic Projectile
The Planetary Science JournalThe ∼200 m s ^−1 impact of a single 400 kg Bjurböle L/LL ordinary chondrite meteorite onto sea ice resulted in the catastrophic disruption of the projectile.
Tomas Kohout +12 more
doaj +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source