Results 31 to 40 of about 284,250 (248)

The Effects of Early Collisional Evolution on Amorphous Water Ice Bodies

The Planetary Science Journal, 2023
Conditions in the outer protoplanetary disk during solar system formation were thought to be favorable for the formation of amorphous water ice (AWI), a glassy phase of water ice.
Jordan K. Steckloff, Gal Sarid, Brandon C. Johnson   +2 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Crater Equilibrium State Characterization given Crater Production from a Single Power Law

The Planetary Science Journal
We generalize the crater equilibrium concept, a terminal state on a cratered surface where the balance of crater production and erasure apparently limits the crater population from further growth. Assuming the crater production consists of a single power
Masatoshi Hirabayashi, Caleb I. Fassett, Emily S. Costello, David A. Minton   +3 more
doaj   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Martian Dynamo Change at ∼4.1 Ga: Evidence from the Magnetic Measurements of the Iota Crater

The Astrophysical Journal
The Martian dynamo evolution is critical for understanding Mars’s interior structure, thermal evolution, and climate change. It has been inferred to shut down at ∼4.1–4.0 Ga based on the magnetic signatures of large impact craters, but be present at ∼3.9
Kuixiang Zhang, Can Huang, Zongyu Yue, Hao Luo, Jipeng Qin, Dongke Chen, Junyu Zhao, Yasong Ge, Aimin Du   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Large Impacts onto the Early Earth: Planetary Sterilization and Iron Delivery

The Planetary Science Journal, 2022
Late accretion onto the Hadean Earth included large impacts that could have influenced early habitability, either by sterilizing the planet or alternatively catalyzing the origin of life by delivering iron required to create a reducing environment ...
Robert I. Citron, Sarah T. Stewart
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Impacts on Ocean Worlds Are Sufficiently Frequent and Energetic to Be of Astrobiological Importance

The Planetary Science Journal
Evidence for the beneficial role of impacts in the creation of urable or habitable environments on Earth prompts the question of whether meteorite impacts could play a similar role at other potentially urable/habitable worlds like Enceladus, Europa, and ...
Shannon M. MacKenzie, Alexandra Pontefract, R. Terik Daly, Jacob J. Buffo, Gordon R. Osinski, Christopher J. Cline II, Mark J. Cintala, Kathleen L. Craft, Mallory J. Kinczyk, Joshua Hedgepeth, Sarah M. Hörst, Abel Méndez, Ben K. D. Pearce, Angela M. Stickle, Steven D. Vance   +14 more
doaj   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source