Results 121 to 130 of about 10,613,174 (259)
Study of the Dynamics of a Single Bubble
EnergiesThe behaviour of bubbles in cavitation and boiling processes is determined by the thermodynamic parameters of the two-phase medium and the intensity of heat and mass transfer, which affect the final dynamic effects.
Anatoliy Pavlenko, Hanna Koshlak
doaj +1 more source
How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome
FEBS Letters, EarlyView.In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini +3 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Preparing case studies for impact within SEP (2021-2027)
Every six years, on a rolling basis, Dutch universities and research institutes are evaluated according to the Strategy Evaluation Protocol (SEP).Based on the experiences with the Strategy Evaluation Protocol (SEP) at the Erasmus University Rotterdam as ...
Evaluating Societal Impact
core +1 more source
, 2022 Hypervelocity impact experiments were performed on two types of cylindrical pressure vessels made from an aluminium-magnesium alloy and unalloyed titanium.
Schneider, E., Schäfer, F., Lambert, M.
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Pressure wave propagation in pressurized thin-walled circular tubes under axial impact
, 2019 The pressurized thin-walled tubes are called as a member of adaptive energy absorbers of which energy absorbing performance can be controlled by variation of internal pressure.
Kuleyin, Hamdi, Gümrük, Recep
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Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Meitian dizhi yu kantanBackgroundIn practical engineering, the waterproof coal pillar usually suffers from different degrees of dynamic load from the overlying strata, and its internal water distribution is non-uniform.
Xiangyang ZHANG +5 more
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