Results 101 to 110 of about 10,613,174 (259)
Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein
FEBS Letters, EarlyView.Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux +7 more
wiley +1 more source
Impact Strategy Development: Discovering your Current Organisational Landscape
This tool guides the research process of discovering a school’s organisational impact landscape as one of the steps when developing an impact strategy.
Evaluating Societal Impact
core +1 more source
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Safety Evaluation of Major Nuclear Facilities According to Debris Flow Occurrence Scenarios
한국해양공학회지This study systematically analyzes the impact of sediment disasters, such as those due to debris flows, on key facilities near the Gori nuclear power plant, aiming to identify limitations in the current safety management system.
Yeonjoong Kim +3 more
doaj +1 more source
MoT-PSA: a two-layer depth-averaged model for simulation of powder snow avalanches on 3-D terrain
Annals of GlaciologyFor snow-avalanche hazard mapping, one needs efficient tools that nevertheless capture the essential physical processes. The code MoT-PSA (Method of Transport – Powder Snow Avalanche) described here is based on the two-layer depth-averaged formulation ...
Hervé Vicari, Dieter Issler
doaj +1 more source
The ubiquitin system in normal and infected germinal center B cells
FEBS Letters, EarlyView.The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis +2 more
wiley +1 more source
Impact Strategy Development: Workshops to Co-create your Strategy
This tool serves as a guide for conducting workshops that enable strategic planning within your school. These workshops provide a structured environment for refection and dialogue, which empowers participants to articulate their aspirations for societal ...
Evaluating Societal Impact
core +1 more source
MathematicsNumerical simulations were conducted to investigate high-pressure water jets in air. The Eulerian multiphase model was employed as the computational framework.
Xianglong Yang, Lei Yang
doaj +1 more source
Depth Design for Rectangular Stilling Well with Oblique Water Intake
Renmin Zhujiang, 2022 When the topography conditions cannot satisfy the needs of the length of the stilling pool during traditional bottom-flow energy dissipation,the energy can be dissipated by increasing the depth and width of the pool.To obtain suitable depths for a ...
XIE Hongying +4 more
doaj
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source