Results 61 to 70 of about 1,249,207 (265)

The Future of Pediatric Hematology‐Oncology Fellowship Training: Reflections on the American Board of Pediatrics Training Model

Pediatric Blood &Cancer, EarlyView.
Scott C. Borinstein, Scott Moerdler, Alexander A. Boucher, Stacy L. Cooper, Rachel A Egler, Erika Friehling, Richard Ho, Catherine McGuinn, Kathryn S. Sutton, Stacey G. Zahler, Leslie Kersun, Jennifer Kesselheim   +11 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Impact-Induced Breakage Behavior During Grain Discharge and Modeling Framework for Discharge Impact Prediction

Agriculture
Grain breakage serves as a primary causative factor for microbial infestation and oxidative deterioration, significantly diminishing product value and resulting in substantial grain waste and economic losses.
Yawen Xiao, Minyue Sun, Anqi Li, Yanlong Han, Yanqin Zhao, Xiaobo Xi, Ruihong Zhang   +6 more
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Identification of Microseismic Signals in Coal Mine Rockbursts Based on Hybrid Feature Selection and a Transformer

Applied Sciences
Deep learning algorithms are pivotal in the identification and classification of microseismic signals in mines subjected to impact pressure. However, conventional machine learning techniques often struggle to balance interpretability, computational ...
Jizhi Zhang, Hongwei Wang, Tianwei Shi
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Scaling Behavior of Sloshing Impact Pressures Based on Event Distribution and Regime Classification

Journal of Marine Science and Engineering
Sloshing in partially filled tanks generates significant impact pressures that threaten the structural integrity of LNG cargo containment systems, and accurate scaling of these impacts remains a critical issue.
Hyung-Min Baek, Jun Kim, Yeonkang Choi, Jimin Hyun, Sung-chul Shin, Yun-ho Shin, Young-Myung Choi, Eun Jung Chae, Hongrae Park, Eun Soo Kim   +9 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Damage on a Solid–Liquid Interface Induced by the Dynamical Behavior of Injected Gas Bubbles in Flowing Mercury

Fluids
Microbubbles have been applied in various fields. In the mercury targets of spallation neutron sources, where cavitation damage is a crucial issue for life estimation, microbubbles are injected into the mercury to absorb the thermal expansion of the ...
Hiroyuki Kogawa, Takashi Wakui, Masatoshi Futakawa   +2 more
doaj   +1 more source