Results 111 to 120 of about 1,148,207 (317)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Superior strain-hardening and strength-ductility synergy by hierarchical L12 phases in a highly (Al, Ti)-added medium-entropy alloy

Journal of Materials Research and Technology
A novel precipitate-strengthened Co–Cr–Ni medium-entropy alloy with a pure “FCC + L12” dual-phase structure is developed by adding a high concentration (6 at.%) of Al and Ti elements.
Shiyu Du, Tuanwei Zhang, Jinyao Ma, Zhiming Jiao, Jianjun Wang, Shengguo Ma, Renlong Xiong, Zhihua Wang   +7 more
doaj   +1 more source

Effect of variable resistance training on lower limb strength and power development: A training study [PDF]

, 2010
The ability to develop high levels of muscular strength and power is considered to be a critical component in many, if not most, sports. Because of this, new training methods are constantly being sought in an attempt to improve strength and power ...
Dobbs, Caleb W.
core  

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Side-to-side differences in bone strength in master jumpers and sprinters [PDF]

, 2011
Introduction: This study evaluated side-to-side difference in tibial bone structure, calf muscle cross-sectional area (CSA) and hopping force in master athletes as a result of training for sports with different magnitudes of inter-leg loading difference.
Korhonen, M, Baur, Chris, Stevens, Sarah, Rittweger, Jörn, Ireland, A, Rittweger, J, Stevens, S, Heinonen, Ari, Degens, Hans, Heinonen, A, Korhonen, Marko, Suominen, Harri, Suominen, H, Degens, H, Baur, C, Ireland, Alex   +15 more
core  

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Phenomenological theory characterization of viscoelastic-plastic response of PA12 under indentation tests

Polymer Testing
Nanoindentation is widely used to study the local time-dependent mechanical behavior of polymer materials. Usually, it can be considered that the indentation depth is the sum of elastic displacement, plastic displacement and time-dependent viscous ...
Gesheng Xiao, Xin Hao, Yuhong Ma, Xuexia Yang, Erqiang Liu   +4 more
doaj   +1 more source

Strength training methods and the work of Arthur Jones

, 2004
This article is not available through ChesterRep. It is available at https://www.asep.org/resources/jep-online/This paper reviews research evidence relating to the strength training advice offered by Arthur Jones, founder and retired Chairman of Nautilus
Bruce-Low, Stewart, Smith, Dave
core  

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source