Results 91 to 100 of about 1,027,905 (267)

On energy mechanism of rate-dependent failure mode evolution in plain weave composite

Polymer Testing
The intricate failure modes and the yet unclear rate dependency of carbon fiber reinforced plain weave composite materials pose a challenge to mechanics researchers.
Yongshuai Wang, Qiong Deng, Lianyang Chen, Haodong Wang, Tao Suo, Cunxian Wang   +5 more
doaj   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Investigation on fracture behavior and prediction model of AA2219-T6 under the coupled effects of temperature and stress state

Journal of Materials Research and Technology
This study systematically investigates the coupled effects of temperature and stress state on the ductile fracture behavior of AA2219-T6. Tensile tests were conducted on specimens with various geometries (TR5, TR10, TD10, and SH) at room temperature, 150 
Cong Liu, Ji Qiu, Buyun Su, Zhiqiang Li, Xiaohu Yao, Xuefeng Shu   +5 more
doaj   +1 more source

Muscle wobbling mass dynamics: eigenfrequency dependencies on activity, impact strength, and ground material. [PDF]

Sci Rep, 2023
Christensen KB, Günther M, Schmitt S, Siebert T.   +3 more
europepmc   +1 more source

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Impact strength of materials [PDF]

Journal of the Franklin Institute, 1974
W. Johnson, Stephen L. Rice
openaire   +2 more sources

Impact of Creatine Supplementation on Strength Training

Quality in Sport
Introduction: Creatine monohydrate supplementation has become a popular ergogenic aid among athletes and fitness enthusiasts aiming not only to enhance strength and muscle mass but also to augment intense resistance training workouts. This study aims to provide a comprehensive review of the current scientific literature on the effects of creatine ...
Izabela Janik, Martyna Kuśmierska, Jakub Kuśmierski   +2 more
openaire   +2 more sources