Results 81 to 90 of about 1,148,207 (317)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

An excellent combination of strength and ductility via hierarchical precipitation structures in Co-free medium-entropy alloys

Journal of Materials Research and Technology
A Co-free non-equiatomic Ni2·5CrFeAl0·25Ti0.25 medium-entropy alloy (MEA) with an excellent strength-ductility synergy was fabricated, which shows a multiphase structure composed of face-centered cubic (FCC), L12 (ordered FCC), and Cr-rich body-centered ...
Jiaxin Zhang, Shengguo Ma, Xiaoxiao Liu, Junwei Qiao, Jianjun Wang, Dan Zhao, Zhiming Jiao, Tuanwei Zhang, Bin Xu, Zhihua Wang   +9 more
doaj   +1 more source

Post-Impact Compression Behaviour of Continuous Fibre Composite Materials

, 1991
PhDCompression-after-impact testing is widely used to assist in the development and selection of materials for aircraft applications. Presently, there are no standard test methods in existence.
Prichard, J.C., Prichard, Jonathan Clive
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Cryogenic mechanical behavior and FCC → HCP phase transformation mechanism in a Si-added CrCoNi medium-entropy alloy under quasi-static and dynamic tension

Materials & Design
The CrCoNiSi0.3 MEA exhibits excellent cryogenic mechanical properties upon both quasi-static and dynamic tension. Under quasi-static tension at cryogenic temperature, the engineering yield and ultimate tensile strengths (UTS) reach 980 MPa and 1800 MPa,
Hui Chang, Tuanwei Zhang, Zhiqiang Li, Jinyao Ma, Jianjun Wang, Dan Zhao, Shengguo Ma, Zhihua Wang   +7 more
doaj   +1 more source

Effects of Combined Strength and Endurance Training on Body Composition, Physical Fitness, and Serum Hormones During a 6-Month Crisis Management Operation

, 2022
Very few studies have examined the impact of training interventions on soldier readiness during an international military operation. Therefore, the present study investigated the effects of combined strength and endurance training on body composition ...
Santtila, Matti, Kyröläinen, Heikki, Ojanen, Tommi, Pihlainen, Kai, Häkkinen, Keijo, Raitanen, Jani   +5 more
core   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Temperature- and stress-dependent creep behavior of SAC305 solder alloy through tensile characterization and CPFE simulation

Materials & Design
Effective characterization of creep properties of Sn3.0Ag0.5Cu (SAC305) solder alloy is of great significance for improving the service reliability of electronic interconnection solder joint and increasing the lifetime of electronic products. The elastic
Yuhong Ma, Dan Zhao, Erqiang Liu, Xuexia Yang, Gesheng Xiao, Xuefeng Shu   +5 more
doaj   +1 more source

Impact of hemodialysis session on handgrip strength

Jornal Brasileiro de Nefrologia, 2015
Handgrip strength (HGS) is a simple and reliable method with a good predictive clinical value for assessing muscle function of patients undergoing hemodialysis (HD). However, there is no consensus regarding the appropriate moment for performing the HGS measurement since the performance of the HGS can be influenced by fluid, electrolyte and blood ...
Ana Paula, Pinto, Christiane Ishikawa, Ramos, Marion Schneider, Meireles, Maria Ayako, Kamimura, Lilian, Cuppari   +4 more
openaire   +2 more sources

Body mass index, muscle strength and physical performance in older adults from eight cohort studies: the HALCyon programme. [PDF]

, 2013
Objective To investigate the associations of body mass index (BMI) and grip strength with objective measures of physical performance (chair rise time, walking speed and balance) including an assessment of sex differences and non-linearity.
Hardy, R, John M. Starr (107707), McNeill Geraldine, Cooper, R, Kuh Diana, Rachel Cooper, Gallacher, John, Holly Syddall, Geraldine McNeill, Starr, John M., John Gallacher, Starr, John M, Yoav Ben-Shlomo, Aihie Sayer, Avan, McNeill, G, Ben-Shlomo, Y, Cyrus Cooper (141250), Panayotes Demakakos (196562), John Gallacher (196569), Martin, Richard M, Syddall Holly, Cyrus Cooper, Cooper Cyrus, Martin, RM, Hardy, Rebecca, Steptoe Andrew, McNeill, Geraldine, Demakakos, Panayotes, Demakakos Panayotes, Starr, JM, Syddall, H, Steptoe, A, ?, ?, John M Starr, HALCyon study team, Avan Aihie Sayer, Geraldine McNeill (107695), Cooper, Rachel, Deary, IJ, Ben-Shlomo, Yoav, Ian J. Deary (107724), Cooper Rachel, Avan Aihie Sayer (188916), Rebecca Hardy, Hardy Rebecca, Deary, Ian J., Martin, Richard M., Ian J Deary, Cooper, Cyrus, Holly Syddall (231862), Syddall, Holly, Richard M. Martin (176602), Sayer, Avan Aihie, Kuh, Diana, Rebecca Hardy (188906), Gallacher, J, Deary, Ian J, Panayotes Demakakos, Martin Richard M., Demakakos, P, Richard M Martin, Yoav Ben-Shlomo (95286), Andrew Steptoe, Diana Kuh, Gallacher John, Kuh, D, Starr John M., Andrew Steptoe (36331), Deary Ian J., Aihie Sayer, A, Cooper, C, Aihie Sayer Avan, Steptoe, Andrew, Ben-Shlomo Yoav, Diana Kuh (188923), Rachel Cooper (188902)   +75 more
core   +1 more source