Results 61 to 70 of about 9,359,353 (213)
Investigating the mechanical properties of cortical bone under dynamic torsional loading
Theoretical and Applied Mechanics LettersBone is a multi-phase, non-homogeneous material that exhibits strain rate sensitivity, and it may fail under compression, tension, torsion, or a combination of these loading.
Jianyin Lei +4 more
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
This tool presents a selection of competences that are relevant for societal impact. The content is presented as a non-exhaustive list of competences that academics can develop for impact-oriented academic activities.
Evaluating Societal Impact
core +1 more source
Microengineering the Liver: Strategies for Constructing Functional Liver‐on‐a‐Chip Devices
ExplorationReliable in vitro liver models are indispensable for researching liver diseases and developing medications. Present 2D/3D cell cultures and animal models inadequately replicate the intricacy of living systems and in vivo conditions, resulting in impaired
Jie Wang +7 more
doaj +1 more source
Formation and deformation mechanisms of gradient structures: The role of strain hardening
Materials & DesignGradient structures (GS) have emerged as a focal point due to their capability to overcome the performance limitations of homogeneous materials. In this study, GS was prepared using the cyclic torsion method for low-carbon (LC) and twinning-induced ...
Taifeng Cao +6 more
doaj +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
TThis tool presents a selection of competences that are relevant for societal impact. The content is presented as a non-exhaustive list of competences that academics can develop for impact-oriented academic activities. Alongside each competence and its
Evaluating Societal Impact
core +1 more source
Impact behaviour of flax/epoxy composite plates [PDF]
, 2015 This paper presents an experimental investigation of the impact behaviour of flax/epoxy composite plates submitted to low-velocity transverse impact.
GNING, Papa-Birame +2 more
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Baozha yu ChongjiLattice mechanical metamaterials have been widely used in various fields due to the lightweight, flexible designability and excellent impact resistance.
Chang LU +10 more
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source