Results 51 to 60 of about 974,662 (268)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Fine regulation of sigma phase achieves excellent mechanical properties in Co-free CrFeNiSi0.2 medium entropy alloy

Journal of Materials Research and Technology
The balance between strength and plasticity is the ultimate objective in the exploration of alloy design. This study focuses on achieving synergy between strength and toughness in the CrFeNiSi0.2 medium entropy alloy through various heat treatments to ...
T.X. Bai, Z.Z. Mao, T.F. Cao, B.H. lin, Q.J. Zha, T.W. Zhang, H. Chang, S.G. Ma, S.Y. Du, Z.H. Wang   +9 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

An excellent combination of strength and ductility via hierarchical precipitation structures in Co-free medium-entropy alloys

Journal of Materials Research and Technology
A Co-free non-equiatomic Ni2·5CrFeAl0·25Ti0.25 medium-entropy alloy (MEA) with an excellent strength-ductility synergy was fabricated, which shows a multiphase structure composed of face-centered cubic (FCC), L12 (ordered FCC), and Cr-rich body-centered ...
Jiaxin Zhang, Shengguo Ma, Xiaoxiao Liu, Junwei Qiao, Jianjun Wang, Dan Zhao, Zhiming Jiao, Tuanwei Zhang, Bin Xu, Zhihua Wang   +9 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cryogenic mechanical behavior and FCC → HCP phase transformation mechanism in a Si-added CrCoNi medium-entropy alloy under quasi-static and dynamic tension

Materials & Design
The CrCoNiSi0.3 MEA exhibits excellent cryogenic mechanical properties upon both quasi-static and dynamic tension. Under quasi-static tension at cryogenic temperature, the engineering yield and ultimate tensile strengths (UTS) reach 980 MPa and 1800 MPa,
Hui Chang, Tuanwei Zhang, Zhiqiang Li, Jinyao Ma, Jianjun Wang, Dan Zhao, Shengguo Ma, Zhihua Wang   +7 more
doaj   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Temperature- and stress-dependent creep behavior of SAC305 solder alloy through tensile characterization and CPFE simulation

Materials & Design
Effective characterization of creep properties of Sn3.0Ag0.5Cu (SAC305) solder alloy is of great significance for improving the service reliability of electronic interconnection solder joint and increasing the lifetime of electronic products. The elastic
Yuhong Ma, Dan Zhao, Erqiang Liu, Xuexia Yang, Gesheng Xiao, Xuefeng Shu   +5 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Temperature-dependent mechanical behavior in a novel hierarchical B2-strengthened high entropy alloy: Microscopic deformation mechanism and yield strength prediction

Materials & Design
Integration of twinning and hierarchical microstructure into a face-centered cubic (FCC) matrix is a novel research approach for advancing high-temperature alloys, enhancing strength without the need for costly heavy elements.
Tuanwei Zhang, Renlong Xiong, Hui Chang, Jinxiong Hou, Dan Zhao, Zhong Wang, Zhouzhu Mao, Tianxiang Bai, Zhiming Jiao, Jianjun Wang, Zhihua Wang   +10 more
doaj   +1 more source