Results 131 to 140 of about 16,071,507 (300)
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
This resource is a (non-exhaustive) collection of materials on stakeholder mapping, analysis, and engagement, based on the experiences and insights of the Evaluating Societal Impact team.
Evaluating Societal Impact
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Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
, 2022 S.211-218The structure of LCA impact assessment is presented and problems of various key elements - e.g. the definition of environmental categories, the classification of impacts into impact categories and the structure of the valuation step are ...
Walz, R., Herrchen, M., Stahl, W.
core +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Impact: health and welfare division report 2003-2005
, 2006 IMPACT members gave a massive endorsement to the Sustaining Progress national deal in March 2003, when they backed it by 9-1 in a national bailout entitled all workers to pay increases worth a total of seven per cent in the first 18 months of the ...
IMPACT
core
Writing your Academic Bio: A Workbook
This tool serves to empower researchers in crafting comprehensive and compelling research profiles. It goes beyond the mere listing of achievements, guiding users to articulate narratives that highlight not only their academic accomplishments but also ...
Evaluating Societal Impact
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The impact of migration on demographic structure and security in Germany
Nowoczesne Systemy ZarządzaniaResearch objectives and hypothesis/research questions The article addresses the research problem: what impact does migration have on demographic structure of Germany, and how can national security be maintained in this context? The aim of the study is to
Bartosz Kozicki
doaj +1 more source