Results 161 to 170 of about 25,604,119 (393)

The atypical KRASQ22K mutation directs TGF‐β response towards partial epithelial‐to‐mesenchymal transition in patient‐derived colorectal cancer tumoroids

Molecular Oncology, EarlyView.
TGF‐β has a complex role in cancer, exhibiting both tumor‐suppressive and tumor‐promoting properties. Using a series of differentiated tumoroids, derived from different stages and mutational background of colorectal cancer patients, we replicate this duality of TGF‐β in vitro. Notably, the atypical but highly aggressive KRASQ22K mutation rendered early‐
Theresia Mair, Philip König, Milena Mijović, Jessica Kalla, Anil Baskan, Loan Tran, Kristina Draganić, Pedro Morata Saldaña, Carlos Uziel Pérez Malla, Janette Pfneissl, Andreas Tiefenbacher, Julijan Kabiljo, Velina S. Atanasova, Lisa Wozelka‐Oltjan, Leonhard Müllauer, Michael Bergmann, Raheleh Sheibani‐Tezerji, Gerda Egger   +17 more
wiley   +1 more source

The Power, Structure, and Practice of Gratitude in Education: A Demonstration of Epistemology and Empirical Research Working Together

, 2018
A growing body of philosophical, psychological, and educational research shows that gratitude has positive effects on mood, relationships, and learning.
Foster, Rob, Wilson, Jane
core  

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

Experimental investigation of engineered geopolymer composite for structural strengthening against blast loads

Defence Technology
The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil infrastructures.
Shan Liu, Chunyuan Liu, Yifei Hao, Yi Zhang, Li Chen, Zhan Li   +5 more
doaj  

Impact of heat treatment on size, structure, and bioactivity of elemental selenium nanoparticles

International Journal of Nanomedicine, 2012
Jinsong Zhang1, Ethan W Taylor2, Xiaochun Wan1, Dungeng Peng31School of Tea and Food Science, Anhui Agricultural University, Anhui, People's Republic of China; 2Department of Nanoscience, Joint School of Nanoscience and Nanoengineering ...
Wan X, Taylor EW, Zhang J, Peng D
doaj  

Private Labeling of Milk and the Impact on Market Structure [PDF]

, 1975
Robert L. Beck, R.G. Alvis
openalex   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

Molecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu, Dilara Demirci, Sude Eris, Bengisu Dayanc, Ece Cakiroglu, Merve Basol, Merve Uysal, Gulcin Cakan‐Akdogan, Fang Liu, Mehmet Ozturk, Gökhan Karakülah, Serif Senturk   +11 more
wiley   +1 more source

The impact of obesity on cardiovascular structure and function: the fetal programming era

Pediatric Health, Medicine and Therapeutics, 2012
Julie St-Pierre1, Luigi Bouchard2,3, Paul Poirier41Department of Pediatrics, Chicoutimi Hospital, Saguenay, QC, Canada; 2Department of Biochemistry, Université de Sherbrooke, Sherbrooke, QC, Canada; 3ECOGENE-21 and Lipid Clinic, Chicoutimi ...
St-Pierre J, Bouchard L, Poirier P
doaj  

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Shatter cones in Illinois: Evidence for metoeritic impacts at Glasford and Des Plaines [PDF]

Shatter cone fragments were recovered from rock cores at two previously suspected, but heretofore unverified, impact structures in Illinois. Both sites are buried features known from geophysical surveys and drill holes.
Mchone, John F., Nelson, W. John, Sargent, Michael L.   +2 more
core   +1 more source