Results 61 to 70 of about 7,030,466 (291)

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

The impact of Early Dark Energy on non-linear structure formation

, 2008
We study non-linear structure formation in high-resolution simulations of Early Dark Energy (EDE) cosmologies and compare their evolution with the standard LCDM model. Extensions of the spherical top-hat collapse model predict that the virial overdensity
Bartelmann, Bryan, Bullock, Conroy, Conroy, Davis, De Lucia, Dolag, Doran, Doran, Doran, Duffy, Efstathiou, Eke, Eke, Espino-Briones, Evrard, Faltenbacher, Faltenbacher, Ferreira, Gao, Haiman, Jenkins, Klypin, Komatsu, Kowalski, Kravtsov, Lacey, Lacey, Liddle, Lin, Linder, Macciò, Macciò, Macciò, Mainini, Manera, Margherita Grossi, Mota, Navarro, Navarro, Navarro, Neto, Nunes, Nunes, Perlmutter, Power, Press, Ratra, Riess, Riess, Sheth, Sheth, Sheth, Smith, Springel, Springel, Springel, Vale, Volker Springel, Wang, Warren, Wetterich, Wetterich, White   +64 more
core   +2 more sources

R&D project announcements and the impact of ownership structure [PDF]

, 2003
This paper examines the stock market reaction to research and development (R&D) announcements made by listed UK companies. R&D projects on average are found to be associated with significant positive abnormal returns.
Danbolt, J., Jones, E.
core   +1 more source

The anti‐CRISPR protein AcrIE8.1 inhibits the type I‐E CRISPR‐Cas system by directly binding to the Cascade subunit Cas11

FEBS Letters, EarlyView.
In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley   +1 more source

Experimental investigation of engineered geopolymer composite for structural strengthening against blast loads

Defence Technology
The recent increase in blast/bombing incidents all over the world has pushed the development of effective strengthening approaches to enhance the blast resistance of existing civil infrastructures.
Shan Liu, Chunyuan Liu, Yifei Hao, Yi Zhang, Li Chen, Zhan Li   +5 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Impact crater morphology and the structure of Europa's ice shell

, 2017
We performed numerical simulations of impact crater formation on Europa to infer the thickness and structure of its ice shell. The simulations were performed using iSALE to test both the conductive ice shell over ocean and the conductive lid over warm ...
Johnson, Brandon C., Silber, Elizabeth A.   +1 more
core   +1 more source

Impact of community structure on information transfer [PDF]

, 2008
The observation that real complex networks have internal structure has important implication for dynamic processes occurring on such topologies. Here we investigate the impact of community structure on a model of information transfer able to deal with ...
Arenas, Àlex, Danon, Leon, Díaz Guilera, Albert   +2 more
core   +2 more sources

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source