Results 81 to 90 of about 1,136,478 (300)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Review of Impact Factors of the Velocity of Large Hailstones for Laboratory Hail Impact Testing Consideration

open access: yesGeosciences, 2020
The terminal velocity of hailstones is an essential quantity in hail research. It is an important value for the kinetic energy of hailstones and has to be carefully considered when laboratory hail impact testing is being planned.
Christian Dieling   +2 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Low velocity impact analysis with NASTRAN [PDF]

open access: yes
A nonlinear elastic force-displacement relationship is used to calculate the transient impact force and local deformation at the point of contact between impactor and target.
Aiello, Robert A.   +2 more
core   +1 more source

Mean-field theory of collective motion due to velocity alignment

open access: yes, 2011
We introduce a system of self-propelled agents (active Brownian particles) with velocity alignment in two spatial dimensions and derive a mean-field theory from the microscopic dynamics via a nonlinear Fokker-Planck equation and a moment expansion of the
Romanczuk, Pawel, Schimansky-Geier, Lutz
core   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

open access: yesFEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon   +6 more
wiley   +1 more source

Coefficient of Restitution of a Squash Ball

open access: yesInternational Scholastic Journal of Science, 2019
The coefficient of restitution of a Double Yellow Dot squash ball was examined at impact velocities ranging from 13 to 29 m/s. A high-speed camera was used with video analysis to record and analyze the motion of a squash ball as it collided against a ...
Marvin Limpijankit
doaj  

Coefficient of Restitution as a Fluctuating Quantity

open access: yes, 2011
The coefficient of restitution of a spherical particle in contact with a flat plate is investigated as a function of the impact velocity. As an experimental observation we notice non-trivial (non-Gaussian) fluctuations of the measured values. For a fixed
A. Hatzes   +6 more
core   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Velocity distribution of fragments of catastrophic impacts [PDF]

open access: yes
Three dimensional velocities of fragments produced by laboratory impact experiments were measured for basalts and pyrophyllites. The velocity distribution of fragments obtained shows that the velocity range of the major fragments is rather narrow, at ...
Kato, Manabu   +2 more
core   +1 more source

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