Results 61 to 70 of about 1,136,478 (300)

Assessing Astrophysical Uncertainties in Direct Detection with Galaxy Simulations

, 2016
We study the local dark matter velocity distribution in simulated Milky Way-mass galaxies, generated at high resolution with both dark matter and baryons.
Brooks, Alyson M., Buckley, Matthew R., Governato, Fabio, Sloane, Jonathan D.   +3 more
core   +1 more source

From the cell membrane to the nucleus: unearthing transport mechanisms for Dynein [PDF]

, 2012
Mutations in the motor protein cytoplasmic dynein have been found to cause Charcot-Marie-Tooth disease, spinal muscular atrophy, and severe intellectual disabilities in humans. In mouse models, neurodegeneration is observed.
A. Friedman, A. G. Hendricks, A. G. Hendricks, A. J. Roberts, A. Kunwar, A. P. Carter, A. V. Kuznetsov, A. V. Kuznetsov, Anotida Madzvamuse, C. Korn, C. L. Brown, Caroline A. Garrett, D. A. Smith, D. Tsygankov, E. Bananis, J. L. Ross, J. Munárriz, J. W. Driver, J. W. Murray, J. W. Wojcieszyn, K. Imamula, K. M. Ori-McKenney, K. S. Zadeh, L. W. Duchen, Laurie Crossley, M. A. Gee, M. B. Harms, M. Bier, M. H. Willemsen, M. Hafezparast, M. N. Weedon, M. Schliwa, M. Schuster, M. Schuster, Majid Hafezparast, O. J. Driskell, P. Ashwin, R. D. Vale, S. A. Burgess, S. Ally, S. C. Schaffner, S. Hoepfner, S. Lubery, S. Mitragotri, S. Mukherji, T. D. Pollard, T. Kon, V. Soppina, W. Deng, X. J. Chen, Y. Gao, Y. Imafuku, Y. Zhang, Y. Zhang   +53 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Numerical analysis of geometrical and mechanical characteristics of the sliding mass influences on impulsive wave generation in dam reservoirs [PDF]

محیط زیست و مهندسی آب
Impulsive waves caused by landslides into lakes and dam reservoirs strike the shores and dam bodies as large waves. The most important factor in their generation is the transfer of momentum from the mass to the water, which can cause damage.
Fateme Maleki, Jalal Bazargan, Ahmad Darudi   +2 more
doaj   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

New Experimental Technique for Dynamic Bending of Composite Materials

Engineering Transactions, 2014
The paper is reporting a new experimental technique to study the dynamic behaviour of composite materials subjected to bending direct impact. It is based on the Hopkinson bar system allowing to observe material behaviour at very high impact velocities ...
Abdellah MASSAQ, Alexis RUSINEK, Maciej KLÓSAK   +2 more
doaj   +1 more source

A REVIEW OF PENETRATION TUNGSTEN BASED PROJECTILE ON DEPTH OF PENETRATION AT ARMOR OF CERAMIC BASED

Jurnal Pertahanan: Media Informasi tentang Kajian dan Strategi Pertahanan yang Mengedepankan Identity, Nasionalism & Integrity, 2020
Nowadays, tungsten-based material is used for the core of projectile, while ceramic-based is used for the main material of armor. Tungsten-based material is chosen because it has density and hardness superior to steel based-material.
Abdul Basyir, Erna Shevilia Agustian, Adhistia Amelia   +2 more
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

DEM-FEM coupling analysis of shot′s energy distribution and target′s residual stress of pneumatic shot peening

Materials Research Express, 2023
Pneumatic shot peening is a widely used surface strengthening method. During the peening process, shots often collide with each other, resulting in large energy loss and small compressive residual stress.
Genshang Wu, Jinggan Shao, Zhanshu He, Saifei Ding, Zhi Zhang, Chao Li, Li Cong   +6 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

Molecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix, Daniel Samaga, Katharina Gehr, Benedek Dankó, Mohamed Schumann, Guido Drexler, Ahmed Alnatsha, Georg Beyer, Ujjwal Mahajan, Martin Selmansberger, Julia Mayerle, Claus Belka, Horst Zitzelsberger, Kirsten Lauber   +13 more
wiley   +1 more source