Results 71 to 80 of about 1,136,478 (300)
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
An Innovative Model to Determine Damping Ratio based on an Experimental Test during Collision [PDF]
Journal of Rehabilitation in Civil EngineeringThis study investigates the damping ratio to evaluate impact force and energy absorption during collisions between adjacent buildings under seismic excitation.
Seyed Mohammad Khatami +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Meitan kexue jishuThe impact velocities of hammer crusher directly affect the crushing effect of rock. In order to study influence of impact velocities of hammer head on the crushing effect and utilization efficiency of fracture energy in green sandstone, macroscopic and ...
Huanshuai ZHAO +6 more
doaj +1 more source
HIGH VELOCITY IMPACT ON TEXTILE REINFORCED COMPOSITES
, 2007 Three types of fabric, 2D woven and 3D stitched, were compared on their impact performance. Tests were performed at three different rates, from quasi-static to high velocity impact (100m/s). The paper addresses the energy absorption capacity of these textiles.
Warnet, L., Akkerman, R., Ravensberg, M.
openaire +2 more sources
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Scaling of the Splash Threshold for Low-Viscosity Fluids
, 2014 The ambient gas pressure is determined for the onset of splashing of low-viscosity liquid drops on smooth dry surfaces as we change the control parameters: drop impact velocity, drop radius, viscosity, surface tension, density, and gas molecular weight ...
Stevens, Cacey S.
core +1 more source