Results 141 to 150 of about 2,073,428 (292)
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Does Expired-Larvacides Impacted to Plankton Abundance and Diversity? [PDF]
, 2019 The using of chemical insecticides for controlling Aedes aegypti can cause mosquitoes resistant to insecticides. One of the natural insecticides commonly used in controlling Ae. aegypti is Bacillus thuringiensis Israelensis (Bti).
Khasanah, I. U. (Isni) +3 more
core
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
The effect of impact damage and circular holes on the compressive strength of a graphite-epoxy laminate [PDF]
Specimens were impacted by 1.27-cm-diameter aluminum spheres with speeds ranging from 52 to 101 m/s. Some specimens were impacted without any applied compressive load and then loaded to failure to determine their residual strength.
Rhodes, M. D. +2 more
core +1 more source
Mechanisms of carbon and nutrient release from acid impacted soils: Investigating competitive sorption and aggregate dispersion [PDF]
, 2018 Dissolved organic carbon (DOC) and associated nutrients are of critical importance to natural biogeochemical cycling. In recent decades, increased amounts of DOC have been observed in Northern Hemisphere surface waters recovering from acid deposition ...
Shavitz, Aaron M
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source