Results 21 to 30 of about 575,905 (318)

Prevalence of cognitive impairments and strengths in the early course of psychosis and depression [PDF]

, 2023
Background Studies investigating cognitive impairments in psychosis and depression have typically compared the average performance of the clinical group against healthy controls (HC), and do not report on the actual prevalence of cognitive impairments or
PRONIA Consortium
core   +1 more source

Reasons for undergoing amyloid imaging among cognitively unimpaired older adults

Annals of Clinical and Translational Neurology, 2021
Objectives Preclinical Alzheimer’s disease (AD) clinical trials screen cognitively unimpaired older adults for biomarker criteria and disclose their results.
Mary M. Ryan, Daniel L. Gillen, Joshua D. Grill   +2 more
doaj   +1 more source

The Sleep Impact on Activity Diary (SIAD): A Novel Assessment of Daytime Functioning in Insomnia

Brain Sciences, 2021
Daytime impairments feature in the diagnostic criteria for insomnia disorder yet are rarely assessed comprehensively in clinical practice and tend to focus on mood and subjective assessment of cognitive competence. In order to gain more information about
Kelsey Bickley, Nicole Lovato, Leon Lack
doaj   +1 more source

Clinical identification of somatosensory impairments in persistent post-amputation pain

, 2021
Sions, Jaclyn MeganAs many as 80% of adults with lower-limb loss experience persistent post-amputation pain in the phantom limb (i.e., amputated portion of the limb) and/or residual limb (i.e., remaining portion of the limb), which is associated with ...
Beisheim, Emma Haldane
core   +1 more source

Generation of a humanized Aβ expressing mouse demonstrating aspects of Alzheimer’s disease-like pathology

Nature Communications, 2021
Most instances of Alzheimer’s disease (AD) are sporadic or not associated with a particular mutation. Here, the authors develop knock-in mice that express wildtype human Aβ under control of the mouse App locus, which may have potential for modelling some
David Baglietto-Vargas, Stefania Forner, Lena Cai, Alessandra C. Martini, Laura Trujillo-Estrada, Vivek Swarup, Marie Minh Thu Nguyen, Kelly Do Huynh, Dominic I. Javonillo, Kristine Minh Tran, Jimmy Phan, Shan Jiang, Enikö A. Kramár, Cristina Nuñez-Diaz, Gabriela Balderrama-Gutierrez, Franklin Garcia, Jessica Childs, Carlos J. Rodriguez-Ortiz, Juan Antonio Garcia-Leon, Masashi Kitazawa, Mohammad Shahnawaz, Dina P. Matheos, Xinyi Ma, Celia Da Cunha, Ken C. Walls, Rahasson R. Ager, Claudio Soto, Antonia Gutierrez, Ines Moreno-Gonzalez, Ali Mortazavi, Andrea J. Tenner, Grant R. MacGregor, Marcelo Wood, Kim N. Green, Frank M. LaFerla   +34 more
doaj   +1 more source

Soft, Rigid, and Hybrid Robotic Exoskeletons for Hand Rehabilitation: Roadmap with Impairment-Oriented Rationale for Devices Design and Selection

Applied Sciences, 2023
In recent decades, extensive attention has been paid to the study and development of robotic devices specifically designed for hand rehabilitation. Accordingly, a many concepts concerning rigid, soft, and hybrid types have emerged in the literature, with
Gabriele Maria Achilli, Cinzia Amici, Mihai Dragusanu, Massimiliano Gobbo, Silvia Logozzo, Monica Malvezzi, Monica Tiboni, Maria Cristina Valigi   +7 more
doaj   +1 more source

Virtual Forest Bathing Programming as Experienced by Disabled Adults with Mobility Impairments and/or Low Energy: A Qualitative Study [PDF]

, 2023
Background: Although access to nature is demonstrated to benefit health and wellbeing, adults with mobility impairments and/or low energy often face barriers in accessing nature environments and nature-based programs.
McEwan, K., Krogh, Alyssa, Alyssa Krogh, Kim Dunlop, Mahnoor Khan, Dunlop, Kim, Kirsten McEwan, McEwan, Kirsten, Dunlop, K., Khan, M., Krogh, K. S., Khan, Mahnoor, Krogh, A., Krogh, Kari S., Kari S. Krogh   +14 more
core   +1 more source

Targeted Control of Gene Expression Using CRISPR-Associated Endoribonucleases

Cells
CRISPR-associated endoribonucleases (Cas RNases) cleave single-stranded RNA in a highly sequence-specific manner by recognizing and binding to short RNA sequences known as direct repeats (DRs).
Sagar J. Parikh, Heather M. Terron, Luke A. Burgard, Derek S. Maranan, Dylan D. Butler, Abigail Wiseman, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring   +8 more
doaj   +1 more source

Intramuscular botulinum toxin prior to comprehensive rehabilitation has no added value for improving motor impairments, gait kinematics and goal attainment in walking children with spastic cerebral palsy

Journal of Rehabilitation Medicine, 2018
Objective: Botulinum toxin (BoNT-A) is widely used in combined treatment for spastic cerebral palsy, but its added value preceding comprehensive rehabilitation for motor impairments, gait, and goal attainment has not been studied.
Fabienne Schasfoort, Robert Pangalila, Emiel M. Sneekes, Coriene Catsman, Jules Becher, Herwin Horemans, Henk J. Stam, Annet J. Dallmeijer, Johannes B.J Bussmann   +8 more
doaj   +1 more source

Recruitment across two decades of NIH-funded Alzheimer’s disease clinical trials

Alzheimer’s Research & Therapy, 2023
Background Timely accrual of a representative sample is a key factor in whether Alzheimer’s disease (AD) clinical trials successfully answer the scientific questions under study.
Marina Ritchie, Daniel L. Gillen, Joshua D. Grill   +2 more
doaj   +1 more source