Results 31 to 40 of about 575,905 (318)

5′ DREDGE: Direct Repeat-Enabled Downregulation of Gene Expression via the 5′ UTR of Target Genes

Cells
Despite the availability of numerous methods for controlling gene expression, there remains a strong need for technologies that maximize two key properties: selectivity and reversibility.
Sagar J. Parikh, Heather M. Terron, Luke A. Burgard, Dylan D. Butler, Frank M. LaFerla, Shelley Lane, Malcolm A. Leissring   +6 more
doaj   +1 more source

IL-1β suppresses cLTP-induced surface expression of GluA1 and actin polymerization via ceramide-mediated Src activation

Journal of Neuroinflammation, 2018
Background Brain inflammation including increases in inflammatory cytokines such as IL-1β is widely believed to contribute to the pathophysiology of Alzheimer’s disease.
Liqi Tong, G. Aleph Prieto, Carl W. Cotman   +2 more
doaj   +1 more source

Estimating attrition in mild-to-moderate Alzheimer’s disease and mild cognitive impairment clinical trials

Alzheimer’s Research & Therapy, 2023
Background Participant retention is a key factor that affects clinical trial integrity. Trial protocols estimate attrition as a function of sample size calculations. Alzheimer’s disease (AD) is an area of active treatment development.
Marina Ritchie, Daniel L. Gillen, Joshua D. Grill   +2 more
doaj   +1 more source

Study partner types and prediction of cognitive performance: implications to preclinical Alzheimer’s trials

Alzheimer’s Research & Therapy, 2019
Background Alzheimer’s disease (AD) clinical trials require enrollment of a participant and a study partner, whose role includes assessing participant cognitive and functional performance.
Michelle M. Nuño, Daniel L. Gillen, Joshua D. Grill, for the Alzheimer’s Disease Cooperative Study   +3 more
doaj   +1 more source

Quality of Life in Young Adults With Cerebral Palsy: A Longitudinal Analysis of the SPARCLE Study

Frontiers in Neurology, 2021
Introduction: While most people with cerebral palsy (CP) will have a life expectancy similar to that of the general population, international research has primarily focused on childhood and adolescence; and knowledge about the quality of life (QoL) of ...
Nicolas Vidart d'Egurbide Bagazgoïtia, Virginie Ehlinger, Carine Duffaut, Jérôme Fauconnier, Silke Schmidt-Schuchert, Ute Thyen, Kate Himmelmann, Marco Marcelli, Catherine Arnaud, Catherine Arnaud   +9 more
doaj   +1 more source

Developing additional competition classes for athletes with intellectual impairments: Conceptual approach and efficacy of an ICF derived measure [PDF]

, 2021
The purpose of para sport classification systems is to minimise the impact of impairment on competition outcome. Currently, athletes with intellectual impairment (II) compete in one class, regardless of the extent of activity limitation resulting from ...
Lemmey, Suzie, Jones, F., Burns, Jan
core   +1 more source

The application of optogenetics in traumatic brain injury research: A narrative review

Brain Circulation
Optogenetics has revolutionized the landscape of research on neurological disorders by enabling high spatial specificity and millisecond-level temporal precision in neuroscience studies.
Cheng-Hao Lin, Bei-Yao Gao, Rui-Dong Ge, Rui Cui, Wen Han, Shan Jiang   +5 more
doaj   +1 more source

Early predictors of language outcomes in Down syndrome: A mini-review

Frontiers in Psychology, 2022
As children with Down syndrome (DS) typically manifest significant delays in language development, the research has pointed out the predictors of later language skills for this clinical population.
Marisa G. Filipe, Sara Cruz, Andreia S. Veloso, Sónia Frota   +3 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

Prevalence of multiple long-term chronic conditions and associated disabilities among community-dwelling adults in Riyadh

Frontiers in Public Health
Background/objectivesSaudi Arabia is experiencing a rapid increase in chronic diseases and disabilities. However, there is a dearth of research on these topics in the Arab world.
Aqeel M. Alenazi, Norah A. Alhwoaimel, Bader A. Alqahtani, Mohammed M. Alshehri, Ahmed S. Alhowimel, Kamlesh Khunti   +5 more
doaj   +1 more source