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Functional Testing for Heparin-Induced Thrombocytopenia Using Whole Blood Multiplate Impedance Aggregometry

open access: closed, 2023
Immune-mediated heparin-induced thrombocytopenia (HIT) occurs when heparin-dependent IgG antibodies bind to heparin/platelet factor 4 (H/PF4) complexes and activate platelets. There is a vast panoply of assays to investigate HIT which can be divided into two groups, antigen-based immunoassays that detect all antibodies against H/PF4 and are used as a ...
Marie‐Christine Morel‐Kopp
openalex   +3 more sources
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Effects of storage conditions on two platelet agonists for whole blood impedance platelet aggregometry in dogs

Veterinary Clinical Pathology, 2018
BackgroundWhole blood impedance platelet aggregometry (Multiplate‐) can be performed with different agonists to evaluate platelet function. Although the manufacturer recommends disposal of stored reagents after 1 month at −20°C or 24 hours at 4°C, reagent integrity after reconstitution under different storage conditions is unknown. If reagent integrity
Sarah B Shropshire, Christine S Olver
exaly   +3 more sources

STUDIES ON PLATELET AGGREGATION BY IMPEDANCE AGGREGOMETRY AND ATP SECRETION IN NON-ANTICOAGULANT BLOOD

open access: closedThrombosis and Haemostasis, 1987
Investigations in vitro on the time-dependent increase in thrombin activityand platelet function have been used tocharacterize the kinetics of the clotting process in nonanticoagulated blood. The test procedures described involve great effort and expense and therefore are not suitable for routine tests in pharmacology and clinical pharmacology.
W. Heptner, J R Suárez, V Lütgendorf
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Repeatability of Platelet Aggregation Characteristics Using Impedance Aggregometry With and Without Aspirin Intervention

open access: closedPhysiology
Nearly 40% of adults over 50-years-old regularly take aspirin for primary or secondary prevention of cardiovascular disease and/or adverse cardiovascular events. The effcacy of aspirin therapy is commonly assessed with light transmission aggregometry.
Auni C. Williams   +3 more
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An assessment of whole blood impedance aggregometry using blood from normal subjects and haemodialysis patients

open access: closedThrombosis Research, 1984
Impedance aggregometry allows the measurement of platelet responses in whole blood as well as in PRP. The variability of haematocrit values encountered when applying this technique to haemodialysis patients prompted an investigation of the effects of red cells on platelet aggregation in whole blood. Collagen induced aggregation was measured in both PRP
M.P. Gordge   +3 more
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The Advantages and Limitations of Impedance Aggregometry in Detection of Heparin-Induced Thrombocytopenia

Clinical Laboratory, 2014
Heparin-induced thrombocytopenia (HIT) represents a serious complication of heparin treatment. IgG antibodies binding platelet factor 4 (PF4) and heparin trigger the clinical manifestations of HIT. However, only a portion of the antibodies have the ability to activate platelets, and these can be identified by a platelet aggregation test (functional ...
L, Slavik   +8 more
openaire   +2 more sources

Effect of platelet count on platelet aggregation measured with impedance aggregometry (Multiplate™ analyzer) and with light transmission aggregometry

Journal of Thrombosis and Haemostasis, 2013
The in vitro evaluation of platelet aggregation is useful to diagnose platelet function disorders [1, 2]; in some laboratories, the test is also used to monitor antiplatelet treatment [3]. Traditionally, platelet aggregation is measured by light transmission aggregometry (LTA), which measures the changes in transmission of a beam of light through a ...
E.A. Femia   +3 more
openaire   +3 more sources

Supplemental Material, supplement - Comparison of Light Transmission Aggregometry With Impedance Aggregometry in Patients on Potent P2Y12 Inhibitors

2020
Supplemental Material, supplement for Comparison of Light Transmission Aggregometry With Impedance Aggregometry in Patients on Potent P2Y12 Inhibitors by Patricia P. Wadowski, Joseph Pultar, Constantin Weikert, Beate Eichelberger, Irene M. Lang, Renate Koppensteiner, Simon Panzer and Thomas Gremmel in Journal of Cardiovascular Pharmacology and ...
Wadowski, Patricia P.   +7 more
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