Results 91 to 100 of about 14,176,106 (302)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Evaluation of Bioelectrical Impedance Analysis for Identifying Overweight Individuals at Increased Cardiometabolic Risk:A Cross-Sectional Study [PDF]

, 2014
OBJECTIVE: To investigate whether bioelectrical impedance analysis could be used to identify overweight individuals at increased cardiometabolic risk, defined as the presence of metabolic syndrome and/or diabetes.DESIGN AND METHODS: Cross-sectional study
Lamb Maxine J. E., Christopher D Byrne, Wilson, J.F., Lamb, M.J.E., Wild, S.H., Lamb, Maxine J E, Byrne, Christopher D, Wild, Sarah H; id_orcid, Wilson James F., Byrne Christopher D., Sarah H Wild, James F Wilson, Wild Sarah H., Wilson, James F; id_orcid, Byrne, Christopher D., Maxine J E Lamb   +15 more
core   +1 more source

Seismic inversion with L_2,0-norm joint-sparse constraint on multi-trace impedance model. [PDF]

Sci Rep, 2022
Dai R, Yang J.
europepmc   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

High-power CMOS current driver with accurate transconductance for electrical impedance tomography [PDF]

, 2014
Current drivers are fundamental circuits in bioimpedance measurements including electrical impedance tomography (EIT). In the case of EIT, the current driver is required to have a large output impedance to guarantee high current accuracy over a wide ...
Demosthenous, A, Constantinou, L, Triantis, I., Demosthenous, A., Bayford, R., Bayford, R, Constantinou, L., Triantis, IF   +7 more
core   +1 more source

Building the Impedance Model of a Real Machine

, 2019
A reliable impedance model of a particle accelerator can be built by combining the beam coupling impedances of all the components. This is a necessary step to be able to evaluate the machine performance limitations, identify the main contributors in case an impedance reduction is required, and study the interaction with other mechanisms such as optics ...
B. Salvant, D. Amorim, S. A. Antipov, S. Arsenyev, M. S. Beck, N. Biancacci, O. S. Brüning, J. V. Campelo, E. Carideo, F. Caspers, A. Farricker, A. Grudiev, T. Kaltenbacher, E. Koukovini-Platia, P. Kramer, A. Lasheen, M. Migliorati, N. Mounet, E. Métral, N. Nasr Esfahani, S. Persichelli, B. K. Popovic, T. L. Rijoff, G. Rumolo, E. N. Shaposhnikova, V. G. Vaccaro, C. Vollinger, N. Wang, C. Zannini, B. Zotter, T. Dalascu, R. Nagaoka, V. V. Smaluk, B. Spataro, S. M. White   +34 more
openaire   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

CPE analysis by local electrochemical impedance spectroscopy [PDF]

, 2006
Constant-phase elements (CPE) are used extensively in equivalent electrical circuits for fitting of experimental impedance data. The CPE behavior is generally attributed to distributed surface reactivity, surface inhomogeneity, roughness or fractal ...
Jorcin, Jean-Baptiste, Pébère, Nadine, Tribollet, Bernard, Orazem, Mark E., Jorcin, Jean Baptiste   +4 more
core   +1 more source

Stability Investigation and Improvement for DC Cascade Systems with Simplified Impedance-based Stability Criterion

CSEE Journal of Power and Energy Systems
In DC distributed power systems (DPSs), the complex impedance interactions possibly lead to DC bus voltage oscillation or collapse. In previous research, the stability analysis of DPSs is implemented based on mathematical analysis in control theory.
Junbin Fang, Zhikang Shuai, Yang Li, Zhibing Wang, Xiangyang Wu, Xia Shen, Z. John Shen   +6 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source