Results 81 to 90 of about 129,245 (304)

Using Imperfect Advance Demand Information in Lost-Sales Inventory Systems with the Option of Returning Inventory [PDF]

, 2018
Motivated by real-life applications, we consider an inventory system where it is possible to collect information about the quantity and timing of future demand in advance.
Dekker, Rommert; id_orcid, van Houtum, G.J.J.A.N.; id_orcid, Topan, E Engin, Topan, E., Dekker, Rommert, Houtum, G.J. (Geert-Jan) van, Tan, Tarkan, van Houtum, G.J.J.A.N., Geert-Jan van Houtum, Topan, E. (Engin), Rommert Dekker, Dekker, R., Topan, E (Engin), Engin Topan, Dekker, R. (Rommert), van Houtum, Geert-Jan, Tan, T Tarkan, Tan, T. (Terence), van Houtum, GJJAN, Tan, T., Topan, Engin, Houtum, GJJAN Geert-Jan van, Tarkan Tan, Tan, T   +23 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

ALTERNATIVE SELECTION FUNCTIONS FOR INFORMATION SET MONTE CARLO TREE SEARCH

Acta Polytechnica, 2014
We evaluate the performance of various selection methods for the Monte Carlo Tree Search algorithm in two-player zero-sum extensive-form games with imperfect information.
Viliam Lisy
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Imperfect Information in Software Design Processes [PDF]

, 2007
The process of designing high-quality software systems is one of the major issues in software engineering research. Over the years, this has resulted in numerous design methods, each with specific qualities and drawbacks.
Noppen, Joost A.R., Noppen, J.A.R.
core   +1 more source

Outage performance of SWIPT-NOMA-CR network with imperfect SIC and CSI

物联网学报, 2023
For the cognitive relay network based on simultaneous wireless information and power transfer (SWIPT) and non-orthogonal multiple access (NOMA), which is termed as SWIPT-NOMA-CR network, considering the practical situation of imperfect successive ...
Zhuhua MA, Liping LUO
doaj   +2 more sources

QUALITY, OBSOLESCENCE AND UNSUSTAINABLE INNOVATION

Ekonomski Vjesnik, 2015
One of the negative side effects of the consumer society and the increasing number of consumer goods available to the average household is the intransparency of product quality, especially product lifetime. There are many examples on failing products and
Rudi Kurz
doaj  

Z-Distance Based IF-THEN Rules

The Scientific World Journal, 2016
Decision making, reasoning, and analysis in real-world problems are complicated by imperfect information. Real-world imperfect information is mainly characterized by two features. In view of this, Professor Zadeh suggested the concept of a Z-number as an
R. A. Aliev, O. H. Huseynov, R. X. Zulfugarova   +2 more
doaj   +1 more source