Results 51 to 60 of about 1,230,707 (291)

Maintenance Modeling for a Multi-State System Under Competing Failures and Imperfect Repairs

Mathematics
A condition-based maintenance modeling approach is proposed for a multi-state system under competing failures and imperfect repairs. The system experiences three states (normal, defective and failed) over its lifecycle. Two competing failure processes, i.
Yanjing Zhang, Xiaohua Meng
doaj   +1 more source

Optimal Circular Economy and Process Maintenance Strategies for an Imperfect Production–Inventory Model with Scrap Returns

Mathematics, 2023
To protect our environment, current firms are committed to the circular economy and process maintenance strategies to reduce the waste of resources. In this way, they can also save costs and create an enterprise image and value.
Rung-Hung Su, Ming-Wei Weng, Chih-Te Yang, Chia-Hsuan Hsu   +3 more
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Goodness-of-fit tests for imperfect maintenance models based on Martingale residuals, varentropy, and probability integral transform [PDF]

Journal of Mahani Mathematical Research
In recent years, various goodness-of-fit tests have been developed to identify the underlying distribution of failure data. In this paper, we extend the application of such tests to evaluate the adequacy of imperfect maintenance models for engineering ...
Fattaneh Nezmpour, Hadi Alizadeh Noughabi, Majid Chahkandi   +2 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Selective maintenance for binary systems using age-based imperfect repair model

, 2012
In many applications, the break between successive missions provides an opportunity to perform maintenance under limited resources. Such maintenance policy is called selective maintenance.
Zuo, M. J, Moghaddass, R, Ming J. Zuo, Pandey, M, Mayank Pandey, Ramin Moghaddass   +5 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Maintenance policy optimisation for multi-component systems considering degradation of components and imperfect maintenance actions

, 2018
International audienceThis article proposes a stochastic optimisation model in order to reduce the long-term total maintenance cost of complex systems. The proposed work is based on the following approaches: (i) optimisation of a cost model for complex ...
Rezg, Nidhal, Castaneda, Leonel,, Castaneda, Leonel, F, Bistorin, Olivier, Martinod, Ronald   +4 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source