Results 61 to 70 of about 182,089 (302)
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Approximating the Randomized Hitting Time Distribution of a Non-stationary Gamma Process [PDF]
The non-stationary gamma process is a non-decreasing stochastic process with independent increments. By this monotonic behavior this stochastic process serves as a natural candidate for modelling time-dependent phenomena such as degradation. In condition-
Frenk, J.B.G., Nicolai, R.P.
core +4 more sources
Engineering Reports, 2022 This article develops a joint model of condition‐based maintenance (CBM) and economic production quantity (EPQ) for a single‐unit manufacturing system.
Jianhua Yang, Xiao Zhao, Mengying Han
doaj +1 more source
Barriers to energy efficiency: evidence from selected sectors [PDF]
, 2003 To combat climate change, it is essential to reduce the use of fossil fuels and minimise greenhouse gas emissions. To help to achieve that objective, energy must be used efficiently.
O'Malley, Eoin +2 more
core +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Integrated condition‐based maintenance modelling and optimisation for offshore wind turbines
Wind Energy, 2021 Maintenance is essential in keeping wind energy assets operating efficiently. With the development of advanced condition monitoring, diagnostics and prognostics, condition‐based maintenance has attracted much attention in the offshore wind industry in ...
Cuong D. Dao +3 more
doaj +1 more source
, 2004 This paper develops a point-mutation model describing the evolutionary dynamics of a population of adult stem cells. Such a model may prove useful for quantitative studies of tissue aging and the emergence of cancer.
A. T. Natarajan +4 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
EAI Endorsed Transactions on Energy Web, 2020 An efficient maintenance allows extension of operating life of system, thus contributing to increase system performance. Computer systems like other systems must operate without interruption and applied strategies of maintenance must be efficiency. This
R. Oudjedi Damerdji, M. Noureddine
doaj +1 more source
Interaction of the oncoprotein transcription factor MYC with its chromatin cofactor WDR5 is essential for tumor maintenance. [PDF]
, 2019 The oncoprotein transcription factor MYC is overexpressed in the majority of cancers. Key to its oncogenic activity is the ability of MYC to regulate gene expression patterns that drive and maintain the malignant state. MYC is also considered a validated
Adams, Clare M. +9 more
core +1 more source