Results 91 to 100 of about 1,620,931 (303)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Paying for treatments? Influences on negotiating clinical need and decision-making for dental implant treatment [PDF]

, 2009
Background: the aim of this study is to examine how clinicians and patients negotiate clinical need and treatment decisions within a context of finite resources.
May, Carl, Cam Donaldson, Field, James, Exley, C. E., May, C.R., Ellis, J. S., Thomason, J Mark, Steele, Jimmy, Jimmy Steele, Exley, Catherine E, Rousseau, N.S., May, Carl R., Rousseau, Nikki, James Field, Exley, C.E., Field James, Ellis Janice S, Catherine E Exley, Carl R May, Ellis, Janice S., Finch Tracy, Field, J., May Carl R, Donaldson, C., Ellis, J.S., Thomason, J. Mark, Ellis, Janice S, Exley, Catherine, Thomason, J. M., Tracy Finch, Thomason J Mark, Finch, Tracy, Janice S Ellis, Rousseau, N. S., Nikki S Rousseau, May, C. R., Steele, J., Thomason, J.M., Rousseau, Nikki S, Finch, T., Rousseau Nikki S, Rousseau, Nikki S., Thomason, John, Donaldson, Cam, Ellis, Janice, May, Carl R, Steele Jimmy, Exley Catherine E, Exley, Catherine E., J Mark Thomason, Donaldson Cam   +50 more
core   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Overcoming single dental implant failure using two small implant support for one crown: five year retrospective study

, 2020
Introduction Overcoming a dental implant failure/osseo-disintegration is still a dilemma for implantologists. Using two implants to support for one crown is a novel approach to resolve this issue.
Doan, N., Truong, L., Doan, J, Doan, N, Reher, P., Reher, P, Doan, J., Truong, L   +7 more
core   +1 more source

Fractography of a neck failure in a double-modular hip implant [PDF]

, 2014
: The tapered joints of modular hip implants are prone to fretting and crevice-corrosion. This can lead to total failure in under a year, especially for heavier, more active implant recipients.

core   +1 more source

Acoustic models of consonant recognition in cochlear implant users [PDF]

, 2007
Normal-hearing adults have no difficulty in recognising consonants accurately, even in moderately adverse listening conditions. By contrast, users of multichannel cochlear implants have difficulty with the accurate perception of consonants, even in good ...
Verschuur, Carl
core   +1 more source

The Risk Factors in Early Failure of Dental Implants: a Retrospective Study

Journal of Dentistry, 2017
Statement of the Problem: Despite the low failure rate of dental implants, recognition of the risk factors can enhance the predictability of failure. Purpose: The aim of this study was to evaluate the risk factors for early implant failure.
Hassan Mohajerani , Roozbeh Roozbayani , Shahram Taherian , Reza Tabrizi   +3 more
doaj  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A Study of the Associated Risk Factors for Early Failure and the Effect of Photofunctionalisation in Full-Arch Immediate Loading Treatment Based on the All-on-Four Concept

Bioengineering
Early implant failure occurring within 1 year after implantation has been attributed to various factors. Particularly, early failure can lead to challenges in maintaining a full-arch prosthetic device, necessitating prompt intervention, including ...
Takashi Uesugi, Yoshiaki Shimoo, Motohiro Munakata, Yu Kataoka, Daisuke Sato, Kikue Yamaguchi, Minoru Sanda, Michiya Fujimaki, Kazuhisa Nakayama, Tae Watanabe, Paulo Malo   +10 more
doaj   +1 more source

Clinical Management of Implant Prostheses in Patients with Bruxism

International Journal of Biomaterials, 2012
There is general agreement that excessive stress to the bone-implant interface may result in implant overload and failure. Early failure of the implant due to excessive loading occurs shortly after uncovering the implant.
Osamu Komiyama, Frank Lobbezoo, Antoon De Laat, Takashi Iida, Tsuyoshi Kitagawa, Hiroshi Murakami, Takao Kato, Misao Kawara   +7 more
doaj   +1 more source