Results 91 to 100 of about 26,977 (247)
Pacing and Clinical Electrophysiology, EarlyView.Abstract Background Implantable cardioverter‐defibrillator (ICD) therapy relies on reliable right ventricular leads for pacing, sensing, and defibrillation. The INVICTA DF4 lead is an active‐fixation, quadripolar design intended to optimize implant workflow and long‐term safety and performance. Methods APOLLO was a prospective, multicenter, single‐arm,
Klaus K. Witte +13 more
wiley +1 more source
First Experience With Extravascular Implantable Cardioverter‐Defibrillator Under Deep Sedation
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background The Extravascular Implantable Cardioverter‐Defibrillator (EV‐ICD) utilizes a substernal lead to provide defibrillation and anti‐tachycardia pacing (ATP) while avoiding transvenous complications. General anesthesia (GA) was applied for implantation procedures in the EV‐ICD pivotal trial and is currently recommended by the ...
Nibras Soubh +9 more
wiley +1 more source
Impact of ICD Presence in Patients With Left Ventricular Assist Devices for End‐Stage Heart Failure
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background The prognostic relevance of implantable cardioverter defibrillator (ICD) in patients with end‐stage heart failure (HF) with left ventricular assist device (LVAD) remains controversial. Objectives To evaluate the prognostic impact of ongoing use of ICD and associated complications in HF‐patients with LVAD‐implantation.
Nafilah Baridwan +11 more
wiley +1 more source
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background Managing non‐functional cardiac implantable electronic device (CIED) leads remains controversial. While extraction is standard for infection, it is unclear whether transvenous lead extraction (TLE) or lead abandonment (LA) provides superior outcomes for superfluous leads.
Karanjeet Chauhan +8 more
wiley +1 more source
Pacing and Clinical Electrophysiology, EarlyView.ABSTRACT Background The role of cardiac resynchronization therapy (CRT) during hospitalization for heart failure (HFH) is uncertain, because hospitalized patients were routinely excluded from landmark CRT trials. Despite this, CRT implantation during HFH is common.
Oliver Rees +5 more
wiley +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic overview of the temporal evolution of the post‐myocardial infarction substrate leading to ventricular tachycardia. Acute ischaemic injury initiates metabolic and electrophysiological disruption, followed by progressive inflammatory, fibrotic and structural remodelling within the infarct border zone.
Mohammed Obeidat +6 more
wiley +1 more source
Benefits of the Implantable Cardioverter-Defibrillator
Journal of the American College of Cardiology, 2008 The state-of-the-art review by Tung and colleagues provides a thoughtful perspective on balancing the benefits and risks of implantable cardioverter-defibrillator (ICD) therapy addressing the concerns of many caring physicians. In this response: 1) the clinical benefits of ICD therapy are reviewed using the evidence base resulting from controlled ...
openaire +2 more sources
Translating cardiovascular ion channel and Ca2+ signalling mechanisms into therapeutic insights
The Journal of Physiology, EarlyView.Abstract figure legend This white paper integrates mechanistic discoveries across ion channel biology, Ca2+ signalling and multiscale cardiovascular physiology to highlight new opportunities for accelerating research and guiding next‐generation therapies. Printed with permission from ®Anita Impagliazzo Medical Illustration. [Correction added on 2 March
Silvia Marchianò +18 more
wiley +1 more source