Results 141 to 150 of about 2,341,915 (339)

Synergistic Osteogenesis After Co‐Administration of cmRNAs Encoding BMP‐2 and BMP‐7 Utilizing a Transcript‐Activated Matrix

Advanced Functional Materials, EarlyView.
This study demonstrates that the dual delivery of BMP‐2/‐7 coding cmRNAs for bone healing is demonstrated as feasible, safe, and highly osteogenic. Compared to single BMP‐2 or BMP‐7 cmRNAs, the combination enhances the production of both mineral and organic components of the extracellular matrix when delivered using a collagen‐HA scaffold, supporting ...
Claudia Del Toro Runzer, Joanna M. Sadowska, Nadia Roumans, Christian Plank, Christopher H. Evans, Fergal J. O'Brien, Martijn van Griensven, Elizabeth R. Balmayor   +7 more
wiley   +1 more source

Improved survival with an implanted defibrillator in patients with coronary disease at high risk for ventricular arrhythmia. Multicenter Automatic Defibrillator Implantation Trial Investigators.

New England Journal of Medicine, 1996
A. Moss, W. Hall, D. Cannom, J. Daubert, Steven L. Higgins, Helmut U. Klein, Joseph H. Levine, Sanjeev Saksena, Albert L. Waldo, David J. Wilber, Mary W. Brown, Moonseong Heo   +11 more
semanticscholar   +1 more source

Blastocyst Pregnancy and Implantation Rates Resulting from Transfer of One Embryo Compared to Transfer of Two Embryos [PDF]

, 2000
D. Marek, M. Langley, Corinne A. Auger, Lorie F. Cram, Kaitlin Doody, Kevin J. Doody   +5 more
openalex   +1 more source

Selective Laser Sintering 3D Printing of Drug‐Loaded Intravitreal Implants

Advanced Functional Materials, EarlyView.
Selective laser sintering enables the fabrication of biodegradable and biocompatible intravitreal implants with tunable microstructures for sustained drug delivery. By modulating laser scanning speed, the polymer matrix architecture is engineered to control the release kinetics of dexamethasone and riboflavin over several months. This approach offers a
Iria Seoane‐Viaño, Carlos Bendicho‐Lavilla, Haya Alfassam, Bárbara Blanco‐Fernández, Abdul W. Basit, Francisco J. Otero‐Espinar   +5 more
wiley   +1 more source

Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway

Journal of Translational Medicine
Background Macrophages phenotypic deviation and immune imbalance play vital roles in pregnancy-associated diseases such as spontaneous miscarriage.
Jing Yang, Longfei Li, Linlin Wang, Ruizhi Chen, Xiaobing Yang, Juanhua Wu, Gang Feng, Jinli Ding, Lianghui Diao, Jiao Chen, Jing Yang   +10 more
doaj   +1 more source

Integrated Single-Cell Analysis Revealed Novel Subpopulations of Foamy Macrophages in Human Atherosclerotic Plaques

Biomolecules
Foam cell formation is a hallmark of atherosclerosis, yet the cellular complexity within foam cells in human plaques remains unexplored. Here, we integrate published single-cell RNA-sequencing, spatial transcriptomic, and chromatin accessibility ...
Yunrui Lu, Shuang Wu, Shiyu Zhu, Jian Shen, Chang Liu, Chaoyue Zhao, Sheng’an Su, Hong Ma, Meixiang Xiang, Yao Xie   +9 more
doaj   +1 more source

Biomaterial Strategies for Targeted Intracellular Delivery to Phagocytes

Advanced Functional Materials, EarlyView.
Phagocytes are essential to a functional immune system, and their behavior defines disease outcomes. Engineered particles offer a strategic opportunity to target phagocytes, harnessing inflammatory modulation in disease. By tuning features like size, shape, and surface, these systems can modulate immune responses and improve targeted treatment for a ...
Kaitlyn E. Woodworth, Neal I. Callaghan, Locke Davenport Huyer   +2 more
wiley   +1 more source

GSTM1 suppresses cardiac fibrosis post-myocardial infarction through inhibiting lipid peroxidation and ferroptosis

Military Medical Research
Background Cardiac fibrosis following myocardial infarction (MI) drives adverse ventricular remodeling and heart failure, with cardiac fibroblasts (CFs) playing a central role.
Kai-Jie Chen, Yue Zhang, Xin-Yi Zhu, Shuo Yu, Yao Xie, Cheng-Jiang Jin, Yi-Min Shen, Si-Yu Zhou, Xiao-Ce Dai, Sheng-An Su, Lan Xie, Zheng-Xing Huang, Hui Gong, Mei-Xiang Xiang, Hong Ma   +14 more
doaj   +1 more source

PROPHYLACTIC IMPLANTATION OF A DEFIBRILLATOR IN PATIENTS WITH MYOCARDIAL INFARCTION AND REDUCED EJECTION FRACTION

, 2002
J. Oss, W. O. Z. Areba, W. J. Ackson, H. E. K. Lein, D. A. J. W. Ilber, D. A. S. C. Annom, J. Ames, P. D. Aubert, S. T. L. H. Iggins, M. B. Rown, M. A. L. A. Ndrews   +10 more
semanticscholar   +1 more source

Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure.

New England Journal of Medicine, 2016
L. Køber, J. Thune, J. Nielsen, J. Haarbo, L. Videbæk, E. Korup, G. Jensen, P. Hildebrandt, F. H. Steffensen, N. Bruun, H. Eiskjær, A. Brandes, A. Thøgersen, F. Gustafsson, K. Egstrup, R. Videbæk, C. Hassager, J. Svendsen, D. Høfsten, C. Torp-Pedersen, S. Pehrson   +20 more
semanticscholar   +1 more source